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sptf-3 Specificity protein transcription factor 3 [ Caenorhabditis elegans ]

Gene ID: 189783, updated on 3-Mar-2024

Summary

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Gene symbol
sptf-3
Gene description
Specificity protein transcription factor 3
Primary source
WormBase:WBGene00012735
Locus tag
CELE_Y40B1A.4
See related
AllianceGenome:WB:WBGene00012735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and chromatin binding activity. Involved in several processes, including generation of neurons; nematode larval development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including MSpaa; g1AR; hypodermal cell; pharyngeal cell; and somatic nervous system. Orthologous to human SP6 (Sp6 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (13360053..13366888, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene WW domain-containing protein Neighboring gene WW domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental functions for the Caenorhabditis elegans Sp protein SPTF-3. Ulm EA, et al. Mech Dev, 2011 Sep-Dec. PMID 21884786
  2. Aging phenomics enabled by quantitative imaging analysis. Chen W, et al. Oncotarget, 2015 Jul 10. PMID 26164083, Free PMC Article
  3. An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways. Hirose T, et al. Nature, 2013 Aug 15. PMID 23851392, Free PMC Article
  4. Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation. Sullivan-Brown JL, et al. Genetics, 2016 Jan. PMID 26434722, Free PMC Article
  5. The translational regulators GCN-1 and ABCF-3 act together to promote apoptosis in C. elegans. Hirose T, et al. PLoS Genet, 2014 Aug. PMID 25101958, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in asymmetric neuroblast division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Specificity protein transcription factor 3
NP_493353.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13360053..13366888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060952.6 → NP_493353.3  Specificity protein transcription factor 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493353.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XW26
    Conserved Domains (4) summary
    COG5048
    Location:311 → 406
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:318 → 338
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:374 → 396
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:360 → 383
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
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