ndx-4 Bis(5'-nucleosyl)-tetraphosphatase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ndx-4
Official Full Name: Bis(5'-nucleosyl)-tetraphosphatase
Primary source: WormBase:WBGene00003581
Locus tag: CELE_Y37H9A.6
See related: AllianceGenome:WB:WBGene00003581
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity and bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Involved in nucleotide metabolic process. Orthologous to human NUDT2 (nudix hydrolase 2). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

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See ndx-4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 2

Sequence:: Chromosome: I; NC_003279.8 (13792639..13794152, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NDX-4 exhibits both hallmarks of a MutT-type enzyme with an ability to hydrolyze 8-oxodGTP and suppress the Escherichia coli mutT mutator phenotype.NDX-4 contributes to genomic stability in vivo in C. elegans.
Title: Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y37H9A.6 (e-PCR)
- UniSTS:318657

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IDA Inferred from Direct Assay more info	PubMed
enables bis(5'-nucleosyl)-tetraphosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in AMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in AMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ATP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in diadenosine tetraphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ribose phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Bis(5'-nucleosyl)-tetraphosphatase

NP_493413.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

13792639..13794152 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061012.7 → NP_493413.1 Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

See identical proteins and their annotated locations for NP_493413.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U2M7

Conserved Domains (1) summary

cd03428
Location:3 → 133

Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...