U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pnmt phenylethanolamine-N-methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 18948, updated on 18-May-2023

Summary

Official Symbol
Pnmtprovided by MGI
Official Full Name
phenylethanolamine-N-methyltransferaseprovided by MGI
Primary source
MGI:MGI:97724
See related
Ensembl:ENSMUSG00000038216 AllianceGenome:MGI:97724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pent
Summary
Predicted to enable phenylethanolamine N-methyltransferase activity. Predicted to be involved in epinephrine biosynthetic process and norepinephrine metabolic process. Predicted to act upstream of or within catecholamine biosynthetic process and methylation. Predicted to be located in several cellular components, including axon; dendrite; and perikaryon. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; brain; gonad; and metanephros. Human ortholog(s) of this gene implicated in Alzheimer's disease; hypertension; and multiple sclerosis. Orthologous to human PNMT (phenylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward adrenal adult (RPKM 262.6) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pnmt in Genome Data Viewer
Location:
11; 11 D
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98277449..98279006)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98386623..98388180)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene START domain containing 3 Neighboring gene titin-cap Neighboring gene post-GPI attachment to proteins 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98254740-98254849 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98261763-98261916

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables phenylethanolamine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phenylethanolamine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phenylethanolamine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within catecholamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in epinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in norepinephrine metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 
located_in varicosity ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phenylethanolamine N-methyltransferase
Names
PNMTase
noradrenaline N-methyltransferase
NP_032916.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008890.3NP_032916.1  phenylethanolamine N-methyltransferase

    See identical proteins and their annotated locations for NP_032916.1

    Status: VALIDATED

    Source sequence(s)
    AL591390
    Consensus CDS
    CCDS25347.1
    UniProtKB/Swiss-Prot
    P40935
    UniProtKB/TrEMBL
    Q0VB50
    Related
    ENSMUSP00000035549.8, ENSMUST00000041301.8
    Conserved Domains (1) summary
    pfam01234
    Location:25290
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98277449..98279006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)