U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prrx1 paired related homeobox 1 [ Mus musculus (house mouse) ]

Gene ID: 18933, updated on 11-Apr-2024

Summary

Official Symbol
Prrx1provided by MGI
Official Full Name
paired related homeobox 1provided by MGI
Primary source
MGI:MGI:97712
See related
Ensembl:ENSMUSG00000026586 AllianceGenome:MGI:97712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K-2; Pmx; Pmx1; Prx1; mHox; MHox1; A230024N07Rik
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; neuronal stem cell population maintenance; and positive regulation of smoothened signaling pathway. Located in nucleus. Is expressed in several structures, including brain; cardiovascular system; embryo mesenchyme; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Orthologous to human PRRX1 (paired related homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 22.0), CNS E11.5 (RPKM 6.8) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Prrx1 in Genome Data Viewer
Location:
1 H2.1; 1 70.53 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (163072688..163142714, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (163245119..163315145, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02849 Neighboring gene predicted gene, 22434 Neighboring gene STARR-seq mESC enhancer starr_02851 Neighboring gene predicted gene, 51850 Neighboring gene STARR-positive B cell enhancer mm9_chr1:165221956-165222257 Neighboring gene predicted gene, 50607 Neighboring gene predicted gene 20471 Neighboring gene golgin, RAB6-interacting Neighboring gene predicted gene, 24940 Neighboring gene STARR-seq mESC enhancer starr_02852 Neighboring gene STARR-seq mESC enhancer starr_02853 Neighboring gene predicted gene, 32333 Neighboring gene predicted gene, 39689

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within artery morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cartilage development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of mesenchymal cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within middle ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within middle ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron fate determination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuronal stem cell population maintenance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of neuron projection regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
paired mesoderm homeobox protein 1
Names
homeobox protein K-2
homeobox protein mHox
muscle homeobox protein
paired-related homeobox protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025570.1NP_001020741.1  paired mesoderm homeobox protein 1 isoform c

    See identical proteins and their annotated locations for NP_001020741.1

    Status: VALIDATED

    Source sequence(s)
    AC120173, AK084387
    Consensus CDS
    CCDS56651.1
    UniProtKB/TrEMBL
    G3UZ44
    Related
    ENSMUSP00000134338.2, ENSMUST00000174397.3
    Conserved Domains (1) summary
    pfam00046
    Location:99150
    Homeobox; Homeobox domain
  2. NM_011127.2NP_035257.1  paired mesoderm homeobox protein 1 isoform a

    See identical proteins and their annotated locations for NP_035257.1

    Status: VALIDATED

    Source sequence(s)
    AK084387, BC092372
    Consensus CDS
    CCDS15427.1
    UniProtKB/Swiss-Prot
    P43271, P63013, Q02810, Q569N6
    Related
    ENSMUSP00000027878.8, ENSMUST00000027878.14
    Conserved Domains (2) summary
    pfam00046
    Location:99151
    Homeobox; Homeobox domain
    pfam03826
    Location:219235
    OAR; OAR domain
  3. NM_175686.3NP_783617.2  paired mesoderm homeobox protein 1 isoform b

    See identical proteins and their annotated locations for NP_783617.2

    Status: VALIDATED

    Source sequence(s)
    AK084387, BC092372
    Consensus CDS
    CCDS15428.1
    UniProtKB/Swiss-Prot
    P63013
    Related
    ENSMUSP00000075203.7, ENSMUST00000075805.13
    Conserved Domains (1) summary
    pfam00046
    Location:99151
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    163072688..163142714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496703.5XP_006496766.1  paired mesoderm homeobox protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006496766.1

    UniProtKB/Swiss-Prot
    P63013
    Conserved Domains (1) summary
    pfam00046
    Location:99151
    Homeobox; Homeobox domain