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Plxna3 plexin A3 [ Mus musculus (house mouse) ]

Gene ID: 18846, updated on 26-Sep-2022

Summary

Official Symbol
Plxna3provided by MGI
Official Full Name
plexin A3provided by MGI
Primary source
MGI:MGI:107683
See related
Ensembl:ENSMUSG00000031398 AllianceGenome:MGI:107683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SEX; Plxa3; Plxn3; Plxn4; PlexA3; mKIAA4078
Summary
Enables semaphorin receptor activity. Involved in nervous system development and positive regulation of cytoskeleton organization. Acts upstream of or within generation of neurons; hippocampus development; and negative chemotaxis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PLXNA3 (plexin A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 44.1), CNS E14 (RPKM 39.8) and 15 other tissues See more
Orthologs
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Genomic context

See Plxna3 in Genome Data Viewer
Location:
X A7.3; X 38.0 cM
Exon count:
35
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73372644..73388295)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74328290..74344689)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 50, member A Neighboring gene microRNA 7092 Neighboring gene predicted gene, 39520 Neighboring gene L antigen family, member 3 Neighboring gene ubiquitin-like 4A Neighboring gene predicted readthrough transcript (NMD candidate), 44504

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4078

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables semaphorin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of axon extension involved in axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branchiomotor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in facial nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron projection extension IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron projection guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in olfactory nerve formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pyramidal neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in semaphorin-plexin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in trigeminal nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of semaphorin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358129.1NP_001345058.1  plexin-A3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL807376, BC093482, CJ192479
    Conserved Domains (7) summary
    cd11273
    Location:22490
    Sema_plexin_A3; The Sema domain, a protein interacting module, of Plexin A3
    smart00423
    Location:789830
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:9361022
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:841935
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:491531
    PSI; Plexin repeat
    pfam08337
    Location:12171765
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    cl15674
    Location:10241111
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  2. NM_008883.2NP_032909.2  plexin-A3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032909.2

    Status: VALIDATED

    Source sequence(s)
    AL807376, CJ192479
    Consensus CDS
    CCDS30228.1
    UniProtKB/Swiss-Prot
    P70208, Q8BWZ5
    UniProtKB/TrEMBL
    A0A158SIT4, Q571A4
    Related
    ENSMUSP00000004326.4, ENSMUST00000004326.4
    Conserved Domains (9) summary
    cd11273
    Location:22490
    Sema_plexin_A3; The Sema domain, a protein interacting module, of Plexin A3
    cd00603
    Location:11261209
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:9361022
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:841935
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10241124
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:491528
    PSI; Plexin repeat
    pfam08337
    Location:12941842
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:546637
    TIG_plexin; TIG domain
    pfam18020
    Location:691785
    TIG_2; TIG domain found in plexin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    73372644..73388295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251258.2XP_030107118.1  plexin-A3 isoform X1

    Conserved Domains (10) summary
    smart00423
    Location:339377
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00603
    Location:9731056
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:783869
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:688782
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:871971
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:485532
    PSI; Plexin repeat
    pfam08337
    Location:11421688
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:394484
    TIG_plexin; TIG domain
    pfam18020
    Location:538632
    TIG_2; TIG domain found in plexin
    cl15693
    Location:47337
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  2. XM_006527902.4XP_006527965.1  plexin-A3 isoform X2

    Conserved Domains (10) summary
    smart00423
    Location:227265
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00603
    Location:861944
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:671757
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:576670
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:759859
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:373420
    PSI; Plexin repeat
    pfam08337
    Location:10301576
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:282372
    TIG_plexin; TIG domain
    pfam18020
    Location:426520
    TIG_2; TIG domain found in plexin
    cl15693
    Location:1225
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  3. XM_036161855.1XP_036017748.1  plexin-A3 isoform X4

    Conserved Domains (7) summary
    cd00603
    Location:427510
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:237323
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:142236
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:325425
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:90139
    PSI; Plexin repeat
    pfam08337
    Location:5951143
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam18020
    Location:286
    TIG_2; TIG domain found in plexin
  4. XM_030251259.1XP_030107119.1  plexin-A3 isoform X3

    Conserved Domains (8) summary
    cd00603
    Location:564647
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:374460
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:279373
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:462562
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:227276
    PSI; Plexin repeat
    pfam08337
    Location:7321280
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:175
    TIG_plexin; TIG domain
    pfam18020
    Location:129223
    TIG_2; TIG domain found in plexin
  5. XM_030251260.2XP_030107120.1  plexin-A3 isoform X4

    Conserved Domains (7) summary
    cd00603
    Location:427510
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:237323
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:142236
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:325425
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:90139
    PSI; Plexin repeat
    pfam08337
    Location:5951143
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam18020
    Location:286
    TIG_2; TIG domain found in plexin
  6. XM_036161854.1XP_036017747.1  plexin-A3 isoform X3

    Related
    ENSMUST00000154062.8
    Conserved Domains (8) summary
    cd00603
    Location:564647
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:374460
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:279373
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:462562
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:227276
    PSI; Plexin repeat
    pfam08337
    Location:7321280
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:175
    TIG_plexin; TIG domain
    pfam18020
    Location:129223
    TIG_2; TIG domain found in plexin
  7. XM_030251261.1XP_030107121.1  plexin-A3 isoform X5

    Conserved Domains (5) summary
    cd00603
    Location:298381
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:108194
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:13107
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:196296
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam08337
    Location:4671013
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
  8. XM_006527903.4XP_006527966.1  plexin-A3 isoform X3

    Conserved Domains (8) summary
    cd00603
    Location:564647
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:374460
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:279373
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:462562
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:227276
    PSI; Plexin repeat
    pfam08337
    Location:7321280
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:175
    TIG_plexin; TIG domain
    pfam18020
    Location:129223
    TIG_2; TIG domain found in plexin