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Plscr2 phospholipid scramblase 2 [ Mus musculus (house mouse) ]

Gene ID: 18828, updated on 5-Jan-2023

Summary

Official Symbol
Plscr2provided by MGI
Official Full Name
phospholipid scramblase 2provided by MGI
Primary source
MGI:MGI:1270860
See related
Ensembl:ENSMUSG00000032372 AllianceGenome:MGI:1270860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding activity; and signaling receptor binding activity. Acts upstream of or within cellular response to lipopolysaccharide. Located in cytoplasm and nucleus. Is expressed in foregut; inner ear; mesothelium; and urogenital mesentery. Orthologous to human PLSCR1 (phospholipid scramblase 1) and PLSCR2 (phospholipid scramblase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 51.4), lung adult (RPKM 5.4) and 2 other tissues See more
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Genomic context

See Plscr2 in Genome Data Viewer
Location:
9; 9 E3.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (92157655..92179805)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (92275602..92297752)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31588 Neighboring gene phospholipid scramblase family, member 5 Neighboring gene predicted gene, 31531 Neighboring gene phospholipid scramblase 1 Neighboring gene microRNA 6386 Neighboring gene RIKEN cDNA 1700057G04 gene Neighboring gene predicted gene 15493 Neighboring gene phospholipid scramblase 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CD4 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables lead ion binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables mercury ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid scramblase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipid scramblase activity ISO
Inferred from Sequence Orthology
more info
 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylserine exposure on apoptotic cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylserine exposure on apoptotic cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in plasma membrane phospholipid scrambling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Fc receptor mediated stimulatory signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lead ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phospholipid scramblase 2
Names
PL scramblase 2
ca(2+)-dependent phospholipid scramblase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195084.1NP_001182013.1  phospholipid scramblase 2

    See identical proteins and their annotated locations for NP_001182013.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the longer transcript. Both variants A and B encode the same protein.
    Source sequence(s)
    AC111125
    Consensus CDS
    CCDS23405.1
    UniProtKB/Swiss-Prot
    Q921P6, Q9DCW2
    Conserved Domains (2) summary
    pfam03803
    Location:84304
    Scramblase; Scramblase
    cl23807
    Location:1061
    WWbp; WW-domain ligand protein
  2. NM_008880.3NP_032906.2  phospholipid scramblase 2

    See identical proteins and their annotated locations for NP_032906.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) differs in the 5' UTR compared to variant A. Both variants A and B encode the same protein.
    Source sequence(s)
    AC111125, AK002410, AW261539
    Consensus CDS
    CCDS23405.1
    UniProtKB/Swiss-Prot
    Q921P6, Q9DCW2
    Related
    ENSMUSP00000034932.8, ENSMUST00000034932.14
    Conserved Domains (2) summary
    pfam03803
    Location:84304
    Scramblase; Scramblase
    cl23807
    Location:1061
    WWbp; WW-domain ligand protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    92157655..92179805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510857.1XP_006510920.1  phospholipid scramblase 2 isoform X1

    Conserved Domains (1) summary
    pfam03803
    Location:97317
    Scramblase
  2. XM_011242676.1XP_011240978.1  phospholipid scramblase 2 isoform X2

    See identical proteins and their annotated locations for XP_011240978.1

    Conserved Domains (1) summary
    cl02043
    Location:28215
    LOR; LURP-one-related