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Plp1 proteolipid protein (myelin) 1 [ Mus musculus (house mouse) ]

Gene ID: 18823, updated on 14-Mar-2023

Summary

Official Symbol
Plp1provided by MGI
Official Full Name
proteolipid protein (myelin) 1provided by MGI
Primary source
MGI:MGI:97623
See related
Ensembl:ENSMUSG00000031425 AllianceGenome:MGI:97623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
jp; Plp; msd; rsh; DM20; jimpy
Summary
Predicted to enable identical protein binding activity. Predicted to be a structural constituent of myelin sheath. Involved in positive regulation of gene expression. Acts upstream of or within several processes, including cell maturation; long-chain fatty acid biosynthetic process; and neurogenesis. Located in myelin sheath. Is expressed in several structures, including alimentary system; cardiovascular system; musculature; nervous system; and sensory organ. Used to study Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 410.7), cortex adult (RPKM 272.7) and 1 other tissue See more
Orthologs
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Genomic context

See Plp1 in Genome Data Viewer
Location:
X F1; X 59.1 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135720897..135739331)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136820148..136838582)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene mortality factor 4 like 2 Neighboring gene cDNA sequence BC065397 Neighboring gene glycine receptor, alpha 4 subunit Neighboring gene predicted gene, 54085 Neighboring gene RAB9B, member RAS oncogene family Neighboring gene predicted gene 15026

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of myelin sheath ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in AMPA selective glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within astrocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within axon development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within axon ensheathment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in central nervous system myelination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within central nervous system myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myelination IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myelination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myelination TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of integrin alphav-beta3 complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in myelin sheath HDA PubMed 
is_active_in myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myelin proteolipid protein
Names
lipophilin
myelin synthesis deficiency
rump shaker

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290561.2NP_001277490.1  myelin proteolipid protein isoform 2

    See identical proteins and their annotated locations for NP_001277490.1

    Status: VALIDATED

    Source sequence(s)
    AK160872, AL672008, BC027010
    Consensus CDS
    CCDS72436.1
    UniProtKB/Swiss-Prot
    P60202
    UniProtKB/TrEMBL
    A0A6P5P893, Q3UYM8
    Related
    ENSMUSP00000108708.2, ENSMUST00000113085.2
    Conserved Domains (1) summary
    pfam01275
    Location:5238
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
  2. NM_001359117.1NP_001346046.1  myelin proteolipid protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671887, AL672008
    Consensus CDS
    CCDS30424.1
    UniProtKB/Swiss-Prot
    Q9WUS9
    UniProtKB/TrEMBL
    A0A6P7QXH4, Q3UYM8
    Conserved Domains (1) summary
    pfam01275
    Location:5273
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
  3. NM_001359118.1NP_001346047.1  myelin proteolipid protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671887, AL672008
    Consensus CDS
    CCDS72436.1
    UniProtKB/TrEMBL
    A0A6P5P893
    Conserved Domains (1) summary
    pfam01275
    Location:5238
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
  4. NM_001359119.1NP_001346048.1  myelin proteolipid protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671887, AL672008
    Consensus CDS
    CCDS30424.1
    UniProtKB/Swiss-Prot
    Q9WUS9
    UniProtKB/TrEMBL
    A0A6P7QXH4, Q3UYM8
    Conserved Domains (1) summary
    pfam01275
    Location:5273
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
  5. NM_001359120.1NP_001346049.1  myelin proteolipid protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671887, AL672008
    Consensus CDS
    CCDS30424.1
    UniProtKB/Swiss-Prot
    Q9WUS9
    UniProtKB/TrEMBL
    A0A6P7QXH4, Q3UYM8
    Conserved Domains (1) summary
    pfam01275
    Location:5273
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
  6. NM_011123.4NP_035253.1  myelin proteolipid protein isoform 1

    See identical proteins and their annotated locations for NP_035253.1

    Status: VALIDATED

    Source sequence(s)
    AK160872, AL672008, BC027010
    Consensus CDS
    CCDS30424.1
    UniProtKB/Swiss-Prot
    P60202, Q9WUS9
    UniProtKB/TrEMBL
    A0A6P7QXH4, Q3UYM8
    Related
    ENSMUSP00000033800.7, ENSMUST00000033800.13
    Conserved Domains (1) summary
    pfam01275
    Location:5273
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    135720897..135739331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001290562.1: Suppressed sequence

    Description
    NM_001290562.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.