U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plod1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 [ Mus musculus (house mouse) ]

Gene ID: 18822, updated on 7-Feb-2023

Summary

Official Symbol
Plod1provided by MGI
Official Full Name
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1provided by MGI
Primary source
MGI:MGI:99907
See related
Ensembl:ENSMUSG00000019055 AllianceGenome:MGI:99907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lh1; Plod; 2410042F05Rik
Summary
Predicted to enable several functions, including L-ascorbic acid binding activity; ferrous iron binding activity; and procollagen-lysine 5-dioxygenase activity. Predicted to be involved in epidermis development and peptidyl-lysine hydroxylation. Located in collagen-containing extracellular matrix. Part of catalytic complex. Is expressed in several structures, including alimentary system; brain; integumental system; sensory organ; and skeleton. Used to study Ehlers-Danlos syndrome. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 1. Orthologous to human PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 37.9), placenta adult (RPKM 37.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Plod1 in Genome Data Viewer
Location:
4 E1; 4 78.57 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (147994210..148021233, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (147909753..147936776, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Friend virus susceptibility 1 Neighboring gene mitofusin 2 Neighboring gene RIKEN cDNA 2510039O18 gene Neighboring gene natriuretic peptide type B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-ascorbic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables procollagen-lysine 5-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables procollagen-lysine 5-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in epidermis development ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-lysine hydroxylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-lysine hydroxylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of catalytic complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
NP_035252.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011122.3NP_035252.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor

    See identical proteins and their annotated locations for NP_035252.1

    Status: VALIDATED

    Source sequence(s)
    AI834765, AK003529, AK137480, BY312508
    Consensus CDS
    CCDS18924.1
    UniProtKB/Swiss-Prot
    Q9R0E2
    UniProtKB/TrEMBL
    A0A8C6MU03
    Related
    ENSMUSP00000019199.8, ENSMUST00000019199.14
    Conserved Domains (1) summary
    smart00702
    Location:563726
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    147994210..148021233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)