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Plcb1 phospholipase C, beta 1 [ Mus musculus (house mouse) ]

Gene ID: 18795, updated on 22-Nov-2020

Summary

Official Symbol
Plcb1provided by MGI
Official Full Name
phospholipase C, beta 1provided by MGI
Primary source
MGI:MGI:97613
See related
Ensembl:ENSMUSG00000051177
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Plcb; AI132408; mKIAA0581; 3110043I21Rik
Expression
Biased expression in frontal lobe adult (RPKM 9.1), cortex adult (RPKM 8.8) and 13 other tissues See more
Orthologs

Genomic context

See Plcb1 in Genome Data Viewer
Location:
2 F3; 2 65.66 cM
Exon count:
35
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (134628084..135317178)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (134786164..135475258)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (134611900..135300994)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14037 Neighboring gene zinc finger, AN1-type domain 1 pseudogene Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene predicted gene, 39941 Neighboring gene RIKEN cDNA 4930545L23 gene Neighboring gene RIKEN cDNA 9630028H03 gene Neighboring gene predicted gene, 31993

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
lamin binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled acetylcholine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
G2/M transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
activation of meiosis involved in egg activation IDA
Inferred from Direct Assay
more info
PubMed 
brain development NAS
Non-traceable Author Statement
more info
PubMed 
cell adhesion IC
Inferred by Curator
more info
PubMed 
cellular response to fluoride ISO
Inferred from Sequence Orthology
more info
 
cellular response to glyceraldehyde ISO
Inferred from Sequence Orthology
more info
 
cellular response to ionomycin ISO
Inferred from Sequence Orthology
more info
 
cellular response to vasopressin ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
erythrocyte differentiation TAS
Traceable Author Statement
more info
PubMed 
fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
glutamate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
inositol trisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
interleukin-12-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
interleukin-15-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
mRNA processing TAS
Traceable Author Statement
more info
PubMed 
macrophage differentiation NAS
Non-traceable Author Statement
more info
PubMed 
memory IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of monocyte extravasation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
oocyte maturation NAS
Non-traceable Author Statement
more info
PubMed 
phosphatidylinositol catabolic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of CD24 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of acrosome reaction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sodium:proton antiporter activity NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
PubMed 
postsynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of retrograde trans-synaptic signaling by endocanabinoid IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to monosaccharide ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
myelin sheath HDA PubMed 
nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Names
PLC-154
PLC-beta-1
phosphoinositide phospholipase C
phosphoinositide phospholipase C-beta-1
phospholipase C-beta-1a
NP_001139302.1
NP_062651.2
XP_006498993.1
XP_036015453.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145830.1NP_001139302.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001139302.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK143153, AL935278, BC058710
    Consensus CDS
    CCDS50729.1
    UniProtKB/Swiss-Prot
    Q9Z1B3
    UniProtKB/TrEMBL
    Q3UPW0
    Related
    ENSMUSP00000105743.1, ENSMUST00000110116.7
    Conserved Domains (7) summary
    cd00275
    Location:677796
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:316643
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:216784
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:22148
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:903939
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:10031172
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:224314
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  2. NM_019677.2NP_062651.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 2

    See identical proteins and their annotated locations for NP_062651.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' exon that contains an in-frame stop codon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK143153, AL935278, BC058710, BU846788
    Consensus CDS
    CCDS16787.1
    UniProtKB/Swiss-Prot
    Q9Z1B3
    UniProtKB/TrEMBL
    Q3UPW0
    Related
    ENSMUSP00000118756.2, ENSMUST00000131552.4
    Conserved Domains (7) summary
    cd00275
    Location:677796
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:316643
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:216784
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:22148
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:903939
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:10031141
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:224314
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    134628084..135317178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498930.4XP_006498993.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1

    Conserved Domains (7) summary
    cd00275
    Location:624743
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:263590
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:163731
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:595
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:850886
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:9501119
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:171261
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  2. XM_036159560.1XP_036015453.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2

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