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Pla2g2d phospholipase A2, group IID [ Mus musculus (house mouse) ]

Gene ID: 18782, updated on 27-Nov-2024

Summary

Official Symbol
Pla2g2dprovided by MGI
Official Full Name
phospholipase A2, group IIDprovided by MGI
Primary source
MGI:MGI:1341796
See related
Ensembl:ENSMUSG00000041202 AllianceGenome:MGI:1341796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GIID; mGIID; Splash; PLA2IID; sPLA2-IID; GIID sPLA2
Summary
Enables calcium-dependent phospholipase A2 activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Involved in glycerophospholipid metabolic process and regulation of acute inflammatory response to antigenic stimulus. Acts upstream of or within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation and negative regulation of T cell proliferation. Located in extracellular region. Is expressed in several structures, including alimentary system; brain; gonad; hemolymphoid system gland; and lung. Orthologous to human PLA2G2D (phospholipase A2 group IID). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 19.2), mammary gland adult (RPKM 12.3) and 7 other tissues See more
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Genomic context

See Pla2g2d in Genome Data Viewer
Location:
4 D3; 4 70.57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138503046..138509363)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138775735..138782052)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group IIF Neighboring gene predicted gene, 42332 Neighboring gene predicted gene, 32871 Neighboring gene STARR-seq mESC enhancer starr_11818 Neighboring gene phospholipase A2, group V Neighboring gene predicted gene, 25280 Neighboring gene phospholipase A2, group IIA (platelets, synovial fluid)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC130437

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in arachidonate secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylcholine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylglycerol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of acute inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
group IID secretory phospholipase A2
Names
phosphatidylcholine 2-acylhydrolase 2D
secretory-type PLA, stroma-associated homolog
NP_001334159.1
NP_035239.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347230.1NP_001334159.1  group IID secretory phospholipase A2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon and uses a downstream translational start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL844178
    Consensus CDS
    CCDS84811.1
    UniProtKB/TrEMBL
    Q3T9Q3
    Related
    ENSMUSP00000101432.2, ENSMUST00000105806.2
  2. NM_011109.3NP_035239.1  group IID secretory phospholipase A2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL844178
    Consensus CDS
    CCDS18833.1
    UniProtKB/Swiss-Prot
    Q3V4B8, Q9JLK0, Q9WVF6
    UniProtKB/TrEMBL
    Q3T9Q3, Q3TYT9
    Related
    ENSMUSP00000030528.3, ENSMUST00000030528.9
    Conserved Domains (1) summary
    cd00125
    Location:20137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    138503046..138509363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)