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Pla2g1b phospholipase A2, group IB, pancreas [ Mus musculus (house mouse) ]

Gene ID: 18778, updated on 8-Dec-2022

Summary

Official Symbol
Pla2g1bprovided by MGI
Official Full Name
phospholipase A2, group IB, pancreasprovided by MGI
Primary source
MGI:MGI:101842
See related
Ensembl:ENSMUSG00000029522 AllianceGenome:MGI:101842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pla2a; sPLA2IB
Summary
Enables phospholipase A2 activity and signaling receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; glycerophospholipid metabolic process; and positive regulation of glomerular visceral epithelial cell apoptotic process. Predicted to act upstream of or within phospholipid catabolic process. Located in extracellular region. Is expressed in liver; lung; and spleen. Orthologous to human PLA2G1B (phospholipase A2 group IB). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward stomach adult (RPKM 11970.9) See more
Orthologs
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Genomic context

See Pla2g1b in Genome Data Viewer
Location:
5; 5 F
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115604201..115612781)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115466142..115474722)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568797 Neighboring gene RIKEN cDNA A930005G22 gene Neighboring gene musashi RNA-binding protein 1 Neighboring gene sirtuin 4 Neighboring gene predicted gene, 42007 Neighboring gene predicted gene, 24265

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC6679

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response in mucosa ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phospholipid catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of podocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phospholipase A2
Names
PLA2-Ib
group IB phospholipase A2
phosphatidylcholine 2-acylhydrolase 1B
NP_001343515.1
NP_001343516.1
NP_035237.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356586.1NP_001343515.1  phospholipase A2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC117735, BY088109
    UniProtKB/TrEMBL
    A0A8C6GXW9
    Related
    ENSMUSP00000120743.2, ENSMUST00000125568.2
    Conserved Domains (1) summary
    smart00085
    Location:23145
    PA2c; Phospholipase A2
  2. NM_001356587.1NP_001343516.1  phospholipase A2 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC117735, AK019009
    Consensus CDS
    CCDS89977.1
    UniProtKB/TrEMBL
    D3Z1N8
    Related
    ENSMUSP00000107702.2, ENSMUST00000112071.8
    Conserved Domains (1) summary
    cl05417
    Location:2465
    PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  3. NM_011107.2NP_035237.1  phospholipase A2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035237.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC117735, AK008668
    Consensus CDS
    CCDS19592.1
    UniProtKB/Swiss-Prot
    Q9D884, Q9Z0Y2
    Related
    ENSMUSP00000031495.5, ENSMUST00000031495.11
    Conserved Domains (1) summary
    smart00085
    Location:24146
    PA2c; Phospholipase A2

RNA

  1. NR_151517.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.
    Source sequence(s)
    AC117735

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115604201..115612781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)