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Prl3d1 prolactin family 3, subfamily d, member 1 [ Mus musculus (house mouse) ]

Gene ID: 18775, updated on 24-Jan-2023

Summary

Official Symbol
Prl3d1provided by MGI
Official Full Name
prolactin family 3, subfamily d, member 1provided by MGI
Primary source
MGI:MGI:97606
See related
Ensembl:ENSMUSG00000057170 AllianceGenome:MGI:97606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pl1; Csh1; Ghd4; PL-I; Pl-1; PL-Ia; mPL-I; PL-I-alpha
Summary
Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Is expressed in several structures, including extraembryonic component; genitourinary system; and genitourinary system mesenchyme. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 74.8) See more
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Genomic context

See Prl3d1 in Genome Data Viewer
Location:
13 A3.1; 13 12.27 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27278172..27284243)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27094189..27100260)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L27a-like Neighboring gene prolactin Neighboring gene prolactin family 3, subfamily d, member 1 Neighboring gene prolactin family 3, subfamily d, member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Clone Names

  • MGC76481

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables prolactin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables prolactin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mammary gland development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of lactation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prolactin-3D1
Names
chorionic somatomammotropin hormone 1
growth hormone d4
placental lactogen 1
placental lactogen I
placental lactogen-I alpha
prolactin-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205322.1NP_001192251.1  prolactin-3D1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001192251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL591843
    Consensus CDS
    CCDS56874.1
    UniProtKB/TrEMBL
    A0A286YC78
    Related
    ENSMUSP00000152890.2, ENSMUST00000225330.2
    Conserved Domains (1) summary
    cd10288
    Location:25224
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
  2. NM_008864.3NP_032890.2  prolactin-3D1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_032890.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK082929, AL591843, CJ214787
    Consensus CDS
    CCDS88428.1
    UniProtKB/TrEMBL
    Q5SY42, Q8BNL4
    Related
    ENSMUSP00000080731.5, ENSMUST00000082079.5
    Conserved Domains (1) summary
    cd10288
    Location:24223
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    27278172..27284243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)