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E4F1 E4F transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 1877, updated on 1-Jun-2020

Summary

Official Symbol
E4F1provided by HGNC
Official Full Name
E4F transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:3121
See related
Ensembl:ENSG00000167967 MIM:603022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E4F
Summary
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in spleen (RPKM 6.6), prostate (RPKM 5.8) and 25 other tissues See more
Orthologs

Genomic context

See E4F1 in Genome Data Viewer
Location:
16p13.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2223488..2235742)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2273490..2285743)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11897 Neighboring gene Sharpr-MPRA regulatory region 5944 Neighboring gene phosphoglycolate phosphatase Neighboring gene deoxyribonuclease 1 like 2 Neighboring gene enoyl-CoA delta isomerase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99614

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
cAMP response element binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle, embryonic IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcription factor E4F1
Names
RING-type E3 ubiquitin transferase E4F1
p120E4F
p50E4F
putative E3 ubiquitin-protein ligase E4F1
transcription factor E4F
NP_001275705.1
NP_001275707.1
NP_004415.4
XP_005255212.1
XP_005255213.1
XP_006720921.1
XP_011520704.1
XP_011520705.1
XP_016878499.1
XP_016878500.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288776.1NP_001275705.1  transcription factor E4F1 isoform 2

    See identical proteins and their annotated locations for NP_001275705.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC014068, BC080524, HY006534
    Consensus CDS
    CCDS73810.1
    UniProtKB/Swiss-Prot
    Q66K89
    Related
    ENSP00000457672.1, ENST00000564139.5
    Conserved Domains (2) summary
    COG5048
    Location:183595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:521541
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001288778.1NP_001275707.1  transcription factor E4F1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons and has two alternate in-frame splice sites in the 3' coding region, compared to variant 1. The encoded protein (isoform 3) is shorter compared to isoform 1.
    Source sequence(s)
    AK225132, BC080524, DN998026, HY006534
    Consensus CDS
    CCDS73809.1
    UniProtKB/Swiss-Prot
    Q66K89
    Related
    ENSP00000456760.1, ENST00000565090.5
    Conserved Domains (4) summary
    sd00017
    Location:194214
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:373389
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:220242
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:384408
    zf-H2C2_2; Zinc-finger double domain
  3. NM_004424.5NP_004415.4  transcription factor E4F1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AC009065
    Consensus CDS
    CCDS32370.1
    Related
    ENSP00000301727.4, ENST00000301727.9
    Conserved Domains (2) summary
    COG5048
    Location:183595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:521541
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2223488..2235742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255155.1XP_005255212.1  transcription factor E4F1 isoform X1

    Conserved Domains (5) summary
    COG5048
    Location:236648
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:574594
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:273295
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:614638
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:506585
    DUF45; Protein of unknown function DUF45
  2. XM_011522402.1XP_011520704.1  transcription factor E4F1 isoform X3

    Conserved Domains (5) summary
    COG5048
    Location:236648
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:574594
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:273295
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:614638
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:506585
    DUF45; Protein of unknown function DUF45
  3. XM_005255156.1XP_005255213.1  transcription factor E4F1 isoform X2

    Conserved Domains (5) summary
    COG5048
    Location:236647
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:573593
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:273295
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:613637
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:505584
    DUF45; Protein of unknown function DUF45
  4. XM_017023010.1XP_016878499.1  transcription factor E4F1 isoform X4

  5. XM_011522403.1XP_011520705.1  transcription factor E4F1 isoform X5

    Conserved Domains (5) summary
    COG5048
    Location:223635
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:561581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260282
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:601625
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:493572
    DUF45; Protein of unknown function DUF45
  6. XM_017023011.1XP_016878500.1  transcription factor E4F1 isoform X6

  7. XM_006720858.1XP_006720921.1  transcription factor E4F1 isoform X7

    Conserved Domains (5) summary
    COG5048
    Location:183594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:520540
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:220242
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:560584
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:452531
    DUF45; Protein of unknown function DUF45

RNA

  1. XR_429636.3 RNA Sequence

  2. XR_243266.4 RNA Sequence

  3. XR_001751853.1 RNA Sequence

  4. XR_002957787.1 RNA Sequence

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