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Pkig protein kinase inhibitor, gamma [ Mus musculus (house mouse) ]

Gene ID: 18769, updated on 9-Mar-2023

Summary

Official Symbol
Pkigprovided by MGI
Official Full Name
protein kinase inhibitor, gammaprovided by MGI
Primary source
MGI:MGI:1343086
See related
Ensembl:ENSMUSG00000035268 AllianceGenome:MGI:1343086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PKIgamma
Summary
Enables cAMP-dependent protein kinase inhibitor activity. Acts upstream of or within negative regulation of protein import into nucleus; negative regulation of protein kinase activity; and negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; tongue; and vertebral axis musculature. Orthologous to human PKIG (cAMP-dependent protein kinase inhibitor gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 82.9), heart adult (RPKM 72.2) and 28 other tissues See more
Orthologs
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Genomic context

See Pkig in Genome Data Viewer
Location:
2 H3; 2 84.4 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163500131..163568078)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163658211..163726158)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tocopherol (alpha) transfer protein-like Neighboring gene serine incorporator 3 Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene predicted gene 16316 Neighboring gene adenosine deaminase intronic regulatory elements Neighboring gene adenosine deaminase Neighboring gene adenosine deaminase upstream regulatory elements

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
cAMP-dependent protein kinase inhibitor gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039390.2NP_001034479.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_001034479.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AK164716, BY283174, BY617655, CJ051558
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    A0A6P7QX37, A0A8C6IC03, Q3TP50
    Related
    ENSMUSP00000096704.3, ENSMUST00000099105.9
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  2. NM_001039391.2NP_001034480.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_001034480.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AK164716, BY343638, BY617655, CJ051558
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    A0A6P7QX37, A0A8C6IC03, Q3TP50
    Related
    ENSMUSP00000068344.7, ENSMUST00000064703.13
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  3. NM_001164053.1NP_001157525.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_001157525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AK164716, BY240874, BY266193, BY617655
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    A0A6P7QX37, A0A8C6IC03, Q3TP50
    Related
    ENSMUSP00000120145.2, ENSMUST00000126182.8
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  4. NM_001164055.1NP_001157527.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_001157527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AL591490
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    A0A6P7QX37, A0A8C6IC03, Q3TP50
    Related
    ENSMUSP00000126223.2, ENSMUST00000164399.8
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  5. NM_001277096.1NP_001264025.1  cAMP-dependent protein kinase inhibitor gamma isoform 2

    See identical proteins and their annotated locations for NP_001264025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 4. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL591490
    Conserved Domains (1) summary
    pfam02827
    Location:269
    PKI; cAMP-dependent protein kinase inhibitor
  6. NM_011106.2NP_035236.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_035236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AV342749, U97170, W75470
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    A0A6P7QX37, A0A8C6IC03, Q3TP50
    Related
    ENSMUSP00000105027.3, ENSMUST00000109400.3
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163500131..163568078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498926.4XP_006498989.1  cAMP-dependent protein kinase inhibitor gamma isoform X1

    See identical proteins and their annotated locations for XP_006498989.1

    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    A0A6P7QX37, A0A8C6IC03, Q3TP50
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  2. XM_030248482.1XP_030104342.1  cAMP-dependent protein kinase inhibitor gamma isoform X1

    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    A0A6P7QX37, A0A8C6IC03, Q3TP50
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  3. XM_030248487.1XP_030104347.1  cAMP-dependent protein kinase inhibitor gamma isoform X1

    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    A0A6P7QX37, A0A8C6IC03, Q3TP50
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor

RNA

  1. XR_003951364.1 RNA Sequence