U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pkig protein kinase inhibitor, gamma [ Mus musculus (house mouse) ]

Gene ID: 18769, updated on 18-Sep-2024

Summary

Official Symbol
Pkigprovided by MGI
Official Full Name
protein kinase inhibitor, gammaprovided by MGI
Primary source
MGI:MGI:1343086
See related
Ensembl:ENSMUSG00000035268 AllianceGenome:MGI:1343086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PKIgamma
Summary
Enables cAMP-dependent protein kinase inhibitor activity. Acts upstream of or within negative regulation of protein import into nucleus; negative regulation of protein kinase activity; and negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; tongue; and vertebral axis musculature. Orthologous to human PKIG (cAMP-dependent protein kinase inhibitor gamma). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Expression
Ubiquitous expression in testis adult (RPKM 82.9), heart adult (RPKM 72.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pkig in Genome Data Viewer
Location:
2 H3; 2 84.4 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163500306..163568078)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163658211..163726158)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2057 Neighboring gene tocopherol (alpha) transfer protein-like Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene serine incorporator 3 Neighboring gene STARR-positive B cell enhancer ABC_E10159 Neighboring gene STARR-positive B cell enhancer ABC_E9208 Neighboring gene STARR-positive B cell enhancer ABC_E819 Neighboring gene STARR-seq mESC enhancer starr_06314 Neighboring gene STARR-positive B cell enhancer ABC_E2058 Neighboring gene predicted gene 16316 Neighboring gene adenosine deaminase intronic regulatory elements Neighboring gene adenosine deaminase upstream regulatory elements Neighboring gene adenosine deaminase Neighboring gene cellular communication network factor 5 Neighboring gene potassium channel, subfamily K, member 15

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (3) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
cAMP-dependent protein kinase inhibitor gamma

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039390.3NP_001034479.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_001034479.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1-5 and 7-19 all encode the same isoform (1).
    Source sequence(s)
    AL591490
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
    Related
    ENSMUSP00000096704.3, ENSMUST00000099105.9
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  2. NM_001039391.2NP_001034480.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_001034480.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1-5 and 7-19 all encode the same isoform (1).
    Source sequence(s)
    AK164716, BY343638, BY617655, CJ051558
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
    Related
    ENSMUSP00000068344.7, ENSMUST00000064703.13
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  3. NM_001164053.2NP_001157525.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_001157525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (1). Variants 1-5 and 7-19 all encode the same isoform (1).
    Source sequence(s)
    AL591490
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
    Related
    ENSMUSP00000120145.2, ENSMUST00000126182.8
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  4. NM_001164055.1NP_001157527.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_001157527.1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
    Related
    ENSMUSP00000126223.2, ENSMUST00000164399.8
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  5. NM_001277096.1NP_001264025.1  cAMP-dependent protein kinase inhibitor gamma isoform 2

    See identical proteins and their annotated locations for NP_001264025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 4. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL591490
    UniProtKB/TrEMBL
    B7ZC22
    Conserved Domains (1) summary
    pfam02827
    Location:269
    PKI; cAMP-dependent protein kinase inhibitor
  6. NM_001420659.1NP_001407588.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
  7. NM_001420660.1NP_001407589.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
  8. NM_001420661.1NP_001407590.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
  9. NM_001420662.1NP_001407591.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
    Related
    ENSMUSP00000120355.2, ENSMUST00000131228.8
  10. NM_001420663.1NP_001407592.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
  11. NM_001420664.1NP_001407593.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
  12. NM_001420665.1NP_001407594.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
  13. NM_001420666.1NP_001407595.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
  14. NM_001420668.1NP_001407597.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
  15. NM_001420669.1NP_001407598.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
  16. NM_001420670.1NP_001407599.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
  17. NM_001420671.1NP_001407600.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
  18. NM_001420672.1NP_001407601.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
  19. NM_001420673.1NP_001407602.1  cAMP-dependent protein kinase inhibitor gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL591490
  20. NM_001420674.1NP_001407603.1  cAMP-dependent protein kinase inhibitor gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/TrEMBL
    B7ZC21
    Related
    ENSMUST00000147385.8
  21. NM_001420675.1NP_001407604.1  cAMP-dependent protein kinase inhibitor gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/TrEMBL
    B7ZC21
  22. NM_001420676.1NP_001407605.1  cAMP-dependent protein kinase inhibitor gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/TrEMBL
    B7ZC21
  23. NM_011106.3NP_035236.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_035236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, compared to variant 4. Variants 1-5 and 7-19 all encode the same isoform (1).
    Source sequence(s)
    AL591490
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
    Related
    ENSMUSP00000105027.3, ENSMUST00000109400.3
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163500306..163568078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)