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Pkdrej polycystin (PKD) family receptor for egg jelly [ Mus musculus (house mouse) ]

Gene ID: 18766, updated on 18-Sep-2024

Summary

Official Symbol
Pkdrejprovided by MGI
Official Full Name
polycystin (PKD) family receptor for egg jellyprovided by MGI
Primary source
MGI:MGI:1338786
See related
Ensembl:ENSMUSG00000052496 AllianceGenome:MGI:1338786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium channel activity. Acts upstream of or within regulation of acrosome reaction. Located in plasma membrane. Is expressed in cochlea. Orthologous to human PKDREJ (polycystin family receptor for egg jelly). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Pkdrej in Genome Data Viewer
Location:
15 E2; 15 40.42 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (85698877..85705934, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85814676..85821733, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10873 Neighboring gene peroxisome proliferator activated receptor alpha Neighboring gene STARR-seq mESC enhancer starr_39399 Neighboring gene STARR-positive B cell enhancer ABC_E5505 Neighboring gene cysteine rich, DPF motif domain containing 1 Neighboring gene tetratricopeptide repeat domain 38 Neighboring gene STARR-seq mESC enhancer starr_39401 Neighboring gene G two S phase expressed protein 1

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of acrosome reaction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sperm plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polycystin family receptor for egg jelly
Names
PKD and REJ homolog
polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly homolog, sea urchin)
polycystic kidney disease and receptor for egg jelly-related protein
receptor for egg jelly-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011105.2NP_035235.2  polycystin family receptor for egg jelly precursor

    See identical proteins and their annotated locations for NP_035235.2

    Status: VALIDATED

    Source sequence(s)
    AC117784
    Consensus CDS
    CCDS27723.1
    UniProtKB/Swiss-Prot
    F8VQF3, Q9Z0T6
    Related
    ENSMUSP00000086352.3, ENSMUST00000064370.6
    Conserved Domains (3) summary
    cd01752
    Location:11151230
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam02010
    Location:130598
    REJ; REJ domain
    pfam08016
    Location:16212051
    PKD_channel; Polycystin cation channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    85698877..85705934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)