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Pkd2 polycystin 2, transient receptor potential cation channel [ Mus musculus (house mouse) ]

Gene ID: 18764, updated on 12-Sep-2021

Summary

Official Symbol
Pkd2provided by MGI
Official Full Name
polycystin 2, transient receptor potential cation channelprovided by MGI
Primary source
MGI:MGI:1099818
See related
Ensembl:ENSMUSG00000034462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PC; TR; PC2; TRPP2; C030034P18Rik
Expression
Ubiquitous expression in limb E14.5 (RPKM 13.0), bladder adult (RPKM 11.6) and 27 other tissues See more
Orthologs
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Genomic context

See Pkd2 in Genome Data Viewer
Location:
5 E5; 5 50.68 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (104599379..104653685)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (104453982..104505819)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (104888476..104934838)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54330 Neighboring gene matrix extracellular phosphoglycoprotein with ASARM motif (bone) Neighboring gene Spp1 5' regulatory region Neighboring gene secreted phosphoprotein 1 Neighboring gene THO complex subunit 2-like Neighboring gene zinc finger protein 33B Neighboring gene predicted gene, 54331

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables HLH domain binding ISO
Inferred from Sequence Orthology
more info
 
enables actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel activity TAS
Traceable Author Statement
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-induced calcium release activity ISO
Inferred from Sequence Orthology
more info
 
enables cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables muscle alpha-actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables muscle alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables outward rectifier potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell signaling by wnt ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to calcium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydrostatic pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cilium organization ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cytoplasmic sequestering of transcription factor ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within detection of mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of nodal flow IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of liver left/right asymmetry ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart looping ISO
Inferred from Sequence Orthology
more info
 
involved_in inorganic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in placenta blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in renal tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in basal cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in basal cortex ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of cation channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of cytoplasmic side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of lumenal side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of polycystin complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polycystin-2
Names
polycystic kidney disease 2 protein homolog
transient receptor potential cation channel subfamily P member 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008861.3NP_032887.3  polycystin-2

    See identical proteins and their annotated locations for NP_032887.3

    Status: VALIDATED

    Source sequence(s)
    AC123687, AK053502, AV517098, BU705556, CX566027
    Consensus CDS
    CCDS19487.1
    UniProtKB/Swiss-Prot
    O35245
    Related
    ENSMUSP00000084041.4, ENSMUST00000086831.4
    Conserved Domains (2) summary
    pfam08016
    Location:265685
    PKD_channel; Polycystin cation channel
    cl08302
    Location:730776
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    104599379..104653685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534815.5XP_006534878.1  polycystin-2 isoform X1

    UniProtKB/Swiss-Prot
    O35245
    Conserved Domains (3) summary
    pfam08016
    Location:266629
    PKD_channel; Polycystin cation channel
    pfam18109
    Location:776810
    Fer4_24; Ferredoxin I 4Fe-4S cluster domain
    cl08302
    Location:674720
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RNA

  1. XR_001784633.3 RNA Sequence

  2. XR_003955591.2 RNA Sequence

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