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Prkd1 protein kinase D1 [ Mus musculus (house mouse) ]

Gene ID: 18760, updated on 16-Oct-2021

Summary

Official Symbol
Prkd1provided by MGI
Official Full Name
protein kinase D1provided by MGI
Primary source
MGI:MGI:99879
See related
Ensembl:ENSMUSG00000002688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PKD; PKD1; Pkcm; Prkcm
Expression
Ubiquitous expression in genital fat pad adult (RPKM 3.1), subcutaneous fat pad adult (RPKM 2.4) and 26 other tissues See more
Orthologs
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Genomic context

See Prkd1 in Genome Data Viewer
Location:
12; 12 B3
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (50388009..50696075, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (50341226..50649271, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (51442218..51750210, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40419 Neighboring gene predicted gene, 40418 Neighboring gene predicted gene, 34523 Neighboring gene predicted gene, 53719 Neighboring gene RIKEN cDNA 1700008C04 gene Neighboring gene predicted gene, 34581 Neighboring gene predicted gene, 40421

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
 
involved_in Golgi vesicle transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydroperoxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of CREB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase D signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein kinase D signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase D1
Names
nPKC-D1
nPKC-mu
protein kinase C mu type
protein kinase C, mu
protein kinase D
NP_001369743.1
NP_001369744.1
NP_001369745.1
NP_032884.2
XP_006515649.1
XP_006515653.1
XP_006515654.1
XP_036013143.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382814.1NP_001369743.1  serine/threonine-protein kinase D1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC099603, AC154543, CT009740, CT010578
    Conserved Domains (4) summary
    cd01239
    Location:414541
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:577836
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    cd20839
    Location:138209
    C1_PKD1_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins
    cd20842
    Location:235328
    C1_PKD1_rpt2; second protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins
  2. NM_001382815.1NP_001369744.1  serine/threonine-protein kinase D1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC099603, AC154543, CT010578
  3. NM_001382816.1NP_001369745.1  serine/threonine-protein kinase D1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT009740
    Conserved Domains (1) summary
    cl21453
    Location:637
    PKc_like; Protein Kinases, catalytic domain
  4. NM_008858.4NP_032884.2  serine/threonine-protein kinase D1 isoform 1

    See identical proteins and their annotated locations for NP_032884.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC099603, AC154543, CT009740, CT010578
    Consensus CDS
    CCDS49059.1
    UniProtKB/Swiss-Prot
    Q62101
    Related
    ENSMUSP00000002765.8, ENSMUST00000002765.9
    Conserved Domains (5) summary
    smart00220
    Location:593845
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:277326
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:422549
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:585844
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00130
    Location:145194
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RNA

  1. NR_168537.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC099603, AC154543, CT009740, CT010578
  2. NR_168538.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009740
  3. NR_168539.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009740
  4. NR_168540.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009740
  5. NR_168541.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009740
  6. NR_168542.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009740
  7. NR_168543.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009740
  8. NR_168544.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009740
  9. NR_168545.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009740

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    50388009..50696075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515586.3XP_006515649.1  serine/threonine-protein kinase D1 isoform X1

    Conserved Domains (4) summary
    cd00029
    Location:277326
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:422549
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:584843
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00130
    Location:145194
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  2. XM_036157250.1XP_036013143.1  serine/threonine-protein kinase D1 isoform X2

    Conserved Domains (3) summary
    cd01239
    Location:259386
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:422681
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    cl00040
    Location:80173
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  3. XM_006515590.5XP_006515653.1  serine/threonine-protein kinase D1 isoform X2

    See identical proteins and their annotated locations for XP_006515653.1

    Conserved Domains (3) summary
    cd01239
    Location:259386
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:422681
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    cl00040
    Location:80173
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  4. XM_006515591.3XP_006515654.1  serine/threonine-protein kinase D1 isoform X3

    Conserved Domains (4) summary
    cd00029
    Location:277326
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:422549
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    pfam00130
    Location:145194
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:585747
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001780432.3 RNA Sequence

  2. XR_001780431.3 RNA Sequence

  3. XR_001780429.3 RNA Sequence

  4. XR_001780428.3 RNA Sequence

  5. XR_004937445.1 RNA Sequence

  6. XR_004937446.1 RNA Sequence

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