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Prkcg protein kinase C, gamma [ Mus musculus (house mouse) ]

Gene ID: 18752, updated on 11-Nov-2024

Summary

Official Symbol
Prkcgprovided by MGI
Official Full Name
protein kinase C, gammaprovided by MGI
Primary source
MGI:MGI:97597
See related
Ensembl:ENSMUSG00000078816 AllianceGenome:MGI:97597
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkcc; Prkcc; PKCgamma
Summary
Enables calcium,diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of protein metabolic process; and response to morphine. Acts upstream of or within chemosensory behavior and regulation of phagocytosis. Located in several cellular components, including dendrite; postsynaptic density; and synaptic membrane. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system gland. Used to study spinocerebellar ataxia type 14. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 14. Orthologous to human PRKCG (protein kinase C gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 34.3), frontal lobe adult (RPKM 31.8) and 5 other tissues See more
Orthologs
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Genomic context

See Prkcg in Genome Data Viewer
Location:
7 A1; 7 1.93 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3352038..3379615)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3303532..3331099)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10422 Neighboring gene acidic ribosomal phosphoprotein P0 pseudogene Neighboring gene myeloid-associated differentiation marker Neighboring gene STARR-seq mESC enhancer starr_17899 Neighboring gene calcium channel, voltage-dependent, gamma subunit 7 Neighboring gene STARR-seq mESC enhancer starr_17900 Neighboring gene predicted gene 9567

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC130440

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemosensory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in learning or memory IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mismatch repair IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mismatch repair ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of response to food IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to morphine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to psychosocial stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to psychosocial stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in calyx of Held IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in calyx of Held IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C gamma type
Names
PKC-gamma
NP_001278363.1
NP_035232.1
XP_036008681.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291434.2NP_001278363.1  protein kinase C gamma type isoform 2

    See identical proteins and their annotated locations for NP_001278363.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC217111, AC245272
    Consensus CDS
    CCDS80649.1
    UniProtKB/TrEMBL
    Q2NKI4
    Related
    ENSMUSP00000131351.2, ENSMUST00000172109.4
    Conserved Domains (4) summary
    cd04026
    Location:158289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05587
    Location:312626
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    cd20833
    Location:3491
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:101154
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
  2. NM_011102.5NP_035232.1  protein kinase C gamma type isoform 1

    See identical proteins and their annotated locations for NP_035232.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC217111, AC245272
    Consensus CDS
    CCDS57470.1
    UniProtKB/Swiss-Prot
    P05697, P63318
    UniProtKB/TrEMBL
    Q3UN66
    Related
    ENSMUSP00000097874.5, ENSMUST00000100301.11
    Conserved Domains (4) summary
    cd04026
    Location:158289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05587
    Location:354677
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    cd20833
    Location:3491
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:101154
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

RNA

  1. NR_184420.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC217111, AC245272
  2. NR_184421.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC217111, AC245272

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3352038..3379615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152788.1XP_036008681.1  protein kinase C gamma type isoform X1

    Conserved Domains (1) summary
    cd05587
    Location:52375
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C