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Prkaca protein kinase, cAMP dependent, catalytic, alpha [ Mus musculus (house mouse) ]

Gene ID: 18747, updated on 27-Nov-2024

Summary

Official Symbol
Prkacaprovided by MGI
Official Full Name
protein kinase, cAMP dependent, catalytic, alphaprovided by MGI
Primary source
MGI:MGI:97592
See related
Ensembl:ENSMUSG00000005469 AllianceGenome:MGI:97592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PKCD; Pkaca
Summary
This gene encodes a member of the serine/threonine protein kinase family. The holoenzyme, protein kinase A (also known as cyclic-AMP dependent protein kinase), mediates cellular response to changes in cyclic-AMP levels. This gene encodes the alpha catalytic subunit of protein kinase A. Protein kinase A-mediated signaling is transduced via phosphorylation of target proteins, and is important for many cellular functions, including mammalian sperm maturation and motility. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Apr 2013]
Expression
Ubiquitous expression in heart adult (RPKM 86.7), subcutaneous fat pad adult (RPKM 59.9) and 28 other tissues See more
Orthologs
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Genomic context

See Prkaca in Genome Data Viewer
Location:
8 C2; 8 40.22 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84699607..84723073)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83972978..83996444)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor L1 Neighboring gene predicted gene 10644 Neighboring gene STARR-positive B cell enhancer ABC_E563 Neighboring gene STARR-positive B cell enhancer ABC_E8943 Neighboring gene anti-silencing function 1B histone chaperone Neighboring gene STARR-positive B cell enhancer ABC_E361 Neighboring gene STARR-seq mESC enhancer starr_22104 Neighboring gene RIKEN cDNA 1700067K01 gene Neighboring gene STARR-positive B cell enhancer ABC_E882 Neighboring gene sterile alpha motif domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cAMP-dependent protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables cAMP-dependent protein kinase activity TAS
Traceable Author Statement
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase A regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cAMP/PKA signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to cold IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glucagon stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cellular response to parathyroid hormone stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesoderm formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of glycolytic process through fructose-6-phosphate IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of glycolytic process through fructose-6-phosphate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_positive_effect protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_positive_effect protein export from nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within protein localization to lipid droplet IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cellular respiration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein processing IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sperm capacitation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spontaneous exocytosis of neurotransmitter ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in axoneme IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with axoneme ISO
Inferred from Sequence Orthology
more info
 
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cAMP-dependent protein kinase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of cAMP-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary base IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleotide-activated protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
 
located_in sperm midpiece ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cAMP-dependent protein kinase catalytic subunit alpha
Names
PKA C-alpha
sperm cAMP-dependent protein kinase catalytic subunit
NP_001264827.1
NP_032880.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277898.1NP_001264827.1  cAMP-dependent protein kinase catalytic subunit alpha isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as Cs and Calpha2) contains an alternate 5'-most exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1. This variant is testis-specific and the encoded isoform does not contain the myristylation signal found in isoform 1 (PMID: 10841548 and PMID: 10982398). There are no publicly available full-length transcripts for this variant, but it is supported by publication data, including PMID: 10982398.
    Source sequence(s)
    AF239743, BQ031203, CB248596, CD807077
    Consensus CDS
    CCDS85574.1
    UniProtKB/Swiss-Prot
    P05132
    Related
    ENSMUSP00000147256.2, ENSMUST00000211558.2
    Conserved Domains (1) summary
    cd14209
    Location:34323
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  2. NM_008854.5NP_032880.1  cAMP-dependent protein kinase catalytic subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_032880.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as Calpha1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC156028, BQ031203, BU059097, CB248596, CD807077
    Consensus CDS
    CCDS22463.1
    UniProtKB/Swiss-Prot
    P05132, Q9JID0
    Related
    ENSMUSP00000005606.7, ENSMUST00000005606.8
    Conserved Domains (1) summary
    cd14209
    Location:42331
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84699607..84723073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)