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Pou1f1 POU domain, class 1, transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 18736, updated on 21-Aug-2019

Summary

Official Symbol
Pou1f1provided by MGI
Official Full Name
POU domain, class 1, transcription factor 1provided by MGI
Primary source
MGI:MGI:97588
See related
Ensembl:ENSMUSG00000004842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dw; Hmp1; Pit1; GHF-1; Pit-1; dwarf; Pit1-rs1
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See Pou1f1 in Genome Data Viewer
Location:
16 C1.3; 16 37.25 cM
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (65520512..65535018)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (65520964..65534316)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34033 Neighboring gene geminin pseudogene Neighboring gene charged multivesicular body protein 2B Neighboring gene predicted gene, 36457 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenohypophysis development ISO
Inferred from Sequence Orthology
more info
 
cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inositol trisphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
somatotropin secreting cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatotropin secreting cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IC
Inferred by Curator
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pituitary-specific positive transcription factor 1
Names
POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)
pituitary specific transcription factor 1, related sequence 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362468.3NP_001349397.2  pituitary-specific positive transcription factor 1 isoform w

    Status: VALIDATED

    Source sequence(s)
    AC118240, CT009578
    Related
    ENSMUSP00000139087.1, ENSMUST00000184525.1
  2. NM_008849.6NP_032875.1  pituitary-specific positive transcription factor 1 isoform a

    See identical proteins and their annotated locations for NP_032875.1

    Status: VALIDATED

    Source sequence(s)
    AC118240, CT009578
    Consensus CDS
    CCDS57033.1
    UniProtKB/Swiss-Prot
    Q00286
    Related
    ENSMUSP00000135113.1, ENSMUST00000176330.7
    Conserved Domains (2) summary
    smart00352
    Location:124198
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:217270
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p6 C57BL/6J

    Range
    65520512..65535018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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