U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

poml-1 PON (paraoxonase) and MEC-6 Like [ Caenorhabditis elegans ]

Gene ID: 187297, updated on 4-Feb-2026
Official Symbol
poml-1
Official Full Name
PON (paraoxonase) and MEC-6 Like
Primary source
WormBase:WBGene00010775
Locus tag
CELE_K11E4.3
See related
AllianceGenome:WB:WBGene00010775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein folding chaperone. Involved in protein maturation. Located in rough endoplasmic reticulum. Is expressed in neurons. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Orthologous to human PON2 (paraoxonase 2) and PON3 (paraoxonase 3). [provided by Alliance of Genome Resources, Jul 2025]
Try the new Gene page
Try the new Transcripts and proteins table
See poml-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (13719143..13722921, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene tRNA-Lys Neighboring gene SH2 domain-containing protein Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene SH3 domain-containing protein Neighboring gene tRNA-Lys Neighboring gene ncRNA

Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans. Chen Y, et al. G3 (Bethesda), 2016 Apr 7. PMID 27172609, Free PMC Article
  2. Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins. Chen Y, et al. Mol Biol Cell, 2016 Apr 15. PMID 26941331, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables arylesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein folding chaperone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
PON (paraoxonase) and MEC-6 Like
NP_510296.2
  • Product from WormBase gene class poml;
    Confirmed by transcript evidence

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13719143..13722921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077895.4 → NP_510296.2  PON (paraoxonase) and MEC-6 Like

    See identical proteins and their annotated locations for NP_510296.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21427
    Conserved Domains (1) summary
    pfam01731
    Location:158 → 243
    Arylesterase; Arylesterase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous