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Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [ Mus musculus (house mouse) ]

Gene ID: 18718, updated on 8-Dec-2022

Summary

Official Symbol
Pip4k2aprovided by MGI
Official Full Name
phosphatidylinositol-5-phosphate 4-kinase, type II, alphaprovided by MGI
Primary source
MGI:MGI:1298206
See related
Ensembl:ENSMUSG00000026737 AllianceGenome:MGI:1298206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pip5k2a
Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; and protein homodimerization activity. Involved in autophagosome-lysosome fusion; megakaryocyte development; and regulation of autophagy. Located in lysosome. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and nose. Orthologous to human PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.5), cerebellum adult (RPKM 9.3) and 24 other tissues See more
Orthologs
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Genomic context

See Pip4k2a in Genome Data Viewer
Location:
2; 2 A3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (18847066..19003101, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (18842255..18998291, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 3363 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene cardiac and apoptosis-related long non-coding RNA Neighboring gene predicted gene, 33534 Neighboring gene RIKEN cDNA 4930426L09 gene Neighboring gene predicted gene, 33592

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phosphate kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Names
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
PI(5)P 4-kinase type II alpha
PI5P4Kalpha
PIP4KII-alpha
diphosphoinositide kinase 2-alpha
phosphatidylinositol-4-phosphate 5-kinase, type II, alpha
NP_001342075.1
NP_001342076.1
NP_001342077.1
NP_001342078.1
NP_032871.3
XP_006497457.1
XP_006497459.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355146.1NP_001342075.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL844855, AL928653, AL928680
    Conserved Domains (1) summary
    smart00330
    Location:62392
    PIPKc; Phosphatidylinositol phosphate kinases
  2. NM_001355147.1NP_001342076.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL844855, AL928653, AL928680
    UniProtKB/TrEMBL
    A0A6P5P345
    Conserved Domains (1) summary
    cl28923
    Location:27352
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
  3. NM_001355148.1NP_001342077.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL844855, AL928653, AL928680
    Conserved Domains (1) summary
    cl02572
    Location:34220
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
  4. NM_001355149.1NP_001342078.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) containss an alternate exon compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL844855, AL928653, AL928680
    Conserved Domains (1) summary
    cl28923
    Location:1249
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
  5. NM_008845.4NP_032871.3  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 1

    See identical proteins and their annotated locations for NP_032871.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK040558, AL844855
    Consensus CDS
    CCDS15712.1
    UniProtKB/Swiss-Prot
    O70172
    UniProtKB/TrEMBL
    A0A6P5NZX4, Q544E3
    Related
    ENSMUSP00000006912.6, ENSMUST00000006912.12
    Conserved Domains (1) summary
    smart00330
    Location:62405
    PIPKc; Phosphatidylinositol phosphate kinases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    18847066..19003101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497396.5XP_006497459.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X2

    Conserved Domains (1) summary
    cl28923
    Location:27341
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
  2. XM_006497394.5XP_006497457.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1

    Conserved Domains (1) summary
    cl28923
    Location:27354
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family