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Piga phosphatidylinositol glycan anchor biosynthesis, class A [ Mus musculus (house mouse) ]

Gene ID: 18700, updated on 17-Jan-2023

Summary

Official Symbol
Pigaprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Aprovided by MGI
Primary source
MGI:MGI:99461
See related
Ensembl:ENSMUSG00000031381 AllianceGenome:MGI:99461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pig-a
Summary
Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Acts upstream of or within GPI anchor biosynthetic process and cellular response to leukemia inhibitory factor. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Is expressed in 1st branchial arch; central nervous system; heart; limb; and medial-nasal process. Used to study autosomal recessive congenital ichthyosis 4B. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 2 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGA (phosphatidylinositol glycan anchor biosynthesis class A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 4.8), liver E14 (RPKM 4.5) and 28 other tissues See more
Orthologs
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Genomic context

See Piga in Genome Data Viewer
Location:
X F5; X 76.49 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (163202776..163216912)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164419780..164433916)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene pirin Neighboring gene predicted gene, 22023 Neighboring gene vascular endothelial growth factor D Neighboring gene ankyrin repeat and SOCS box-containing 11 Neighboring gene chromobox protein homolog 1-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase subunit A; N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein
Names
glcNAc-PI synthesis protein
phosphatidylinositol glycan, class A
phosphatidylinositol-glycan biosynthesis class A protein
phosphatidylinositolglycan class A
NP_035211.2
XP_011246095.1
XP_017173917.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011081.4NP_035211.2  phosphatidylinositol N-acetylglucosaminyltransferase subunit A

    See identical proteins and their annotated locations for NP_035211.2

    Status: VALIDATED

    Source sequence(s)
    AL732475
    Consensus CDS
    CCDS30522.1
    UniProtKB/Swiss-Prot
    Q64323, Q8CCQ6
    UniProtKB/TrEMBL
    A0A8C6GRS1, A2AIH5
    Related
    ENSMUSP00000033754.8, ENSMUST00000033754.15
    Conserved Domains (1) summary
    cd03796
    Location:34433
    GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

RNA

  1. NR_152315.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL732475
    Related
    ENSMUST00000112257.10

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    163202776..163216912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318428.3XP_017173917.1  N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein isoform X1

    UniProtKB/Swiss-Prot
    Q64323, Q8CCQ6
    UniProtKB/TrEMBL
    A0A8C6GRS1, A2AIH5
    Related
    ENSMUSP00000107874.2, ENSMUST00000112255.8
    Conserved Domains (1) summary
    cd03796
    Location:34433
    GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins
  2. XM_011247793.3XP_011246095.1  N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein isoform X2

    Related
    ENSMUSP00000146731.2, ENSMUST00000208697.2
    Conserved Domains (1) summary
    cl10013
    Location:13208
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology