U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

E2F2 E2F transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 1870, updated on 19-Feb-2023

Summary

Official Symbol
E2F2provided by HGNC
Official Full Name
E2F transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:3114
See related
Ensembl:ENSG00000007968 MIM:600426; AllianceGenome:HGNC:3114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E2F-2
Summary
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 17.6), lymph node (RPKM 3.1) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See E2F2 in Genome Data Viewer
Location:
1p36.12
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23505212..23531233, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23340999..23365799, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23832930..23857725, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903875 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene Sharpr-MPRA regulatory region 12987 Neighboring gene uncharacterized LOC101928163 Neighboring gene Sharpr-MPRA regulatory region 6048 Neighboring gene uncharacterized LOC124903876 Neighboring gene Sharpr-MPRA regulatory region 7496

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA polymerase II transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of Rb-E2F complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004091.4NP_004082.1  transcription factor E2F2

    See identical proteins and their annotated locations for NP_004082.1

    Status: REVIEWED

    Source sequence(s)
    AF086395, AL021154, L22846
    Consensus CDS
    CCDS236.1
    UniProtKB/Swiss-Prot
    Q14209, Q7Z6H1
    Related
    ENSP00000355249.2, ENST00000361729.3
    Conserved Domains (2) summary
    cd14660
    Location:206306
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:131194
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    23505212..23531233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448092.1XP_047304048.1  transcription factor E2F2 isoform X4

  2. XM_011540870.4XP_011539172.1  transcription factor E2F2 isoform X3

    Conserved Domains (1) summary
    cd14660
    Location:206306
    E2F_DD; Dimerization domain of E2F transcription factors
  3. XM_047448091.1XP_047304047.1  transcription factor E2F2 isoform X2

  4. XM_011540871.3XP_011539173.1  transcription factor E2F2 isoform X6

    See identical proteins and their annotated locations for XP_011539173.1

    Conserved Domains (1) summary
    cd14660
    Location:10110
    E2F_DD; Dimerization domain of E2F transcription factors
  5. XM_011540868.4XP_011539170.1  transcription factor E2F2 isoform X1

    Conserved Domains (2) summary
    cd14660
    Location:204304
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:131194
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  6. XM_047448093.1XP_047304049.1  transcription factor E2F2 isoform X6

  7. XM_047448094.1XP_047304050.1  transcription factor E2F2 isoform X6

  8. XM_005245749.4XP_005245806.1  transcription factor E2F2 isoform X6

    See identical proteins and their annotated locations for XP_005245806.1

    Conserved Domains (1) summary
    cd14660
    Location:10110
    E2F_DD; Dimerization domain of E2F transcription factors
  9. XM_005245748.4XP_005245805.1  transcription factor E2F2 isoform X5

    Conserved Domains (1) summary
    cd14660
    Location:18118
    E2F_DD; Dimerization domain of E2F transcription factors

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_014040926.1 Reference GRCh38.p14 PATCHES

    Range
    276417..301212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    23340999..23365799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)