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E2F2 E2F transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 1870, updated on 1-Jun-2020

Summary

Official Symbol
E2F2provided by HGNC
Official Full Name
E2F transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:3114
See related
Ensembl:ENSG00000007968 MIM:600426
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E2F-2
Summary
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 17.6), lymph node (RPKM 3.1) and 8 other tissues See more
Orthologs

Genomic context

See E2F2 in Genome Data Viewer
Location:
1p36.12
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (23505696..23531250, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23832920..23857712, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A3 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC101928163 Neighboring gene Sharpr-MPRA regulatory region 7496 Neighboring gene uncharacterized LOC105376859

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
contributes_to RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
lens fiber cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004091.4NP_004082.1  transcription factor E2F2

    See identical proteins and their annotated locations for NP_004082.1

    Status: REVIEWED

    Source sequence(s)
    AF086395, AL021154, L22846
    Consensus CDS
    CCDS236.1
    UniProtKB/Swiss-Prot
    Q14209
    Related
    ENSP00000355249.2, ENST00000361729.3
    Conserved Domains (2) summary
    cd14660
    Location:206306
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:131194
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    23505696..23531250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540870.3XP_011539172.1  transcription factor E2F2 isoform X2

    Conserved Domains (2) summary
    cd14660
    Location:206306
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:131194
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  2. XM_011540871.2XP_011539173.1  transcription factor E2F2 isoform X4

    See identical proteins and their annotated locations for XP_011539173.1

    Conserved Domains (1) summary
    cd14660
    Location:10110
    E2F_DD; Dimerization domain of E2F transcription factors
  3. XM_011540868.3XP_011539170.1  transcription factor E2F2 isoform X1

    Conserved Domains (2) summary
    cd14660
    Location:204304
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:131194
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  4. XM_005245749.3XP_005245806.1  transcription factor E2F2 isoform X4

    See identical proteins and their annotated locations for XP_005245806.1

    Conserved Domains (1) summary
    cd14660
    Location:10110
    E2F_DD; Dimerization domain of E2F transcription factors
  5. XM_005245748.3XP_005245805.1  transcription factor E2F2 isoform X3

    Conserved Domains (1) summary
    cd14660
    Location:18118
    E2F_DD; Dimerization domain of E2F transcription factors

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_014040926.1 Reference GRCh38.p13 PATCHES

    Range
    276417..301212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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