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APLNR apelin receptor [ Homo sapiens (human) ]

Gene ID: 187, updated on 5-Dec-2021

Summary

Official Symbol
APLNRprovided by HGNC
Official Full Name
apelin receptorprovided by HGNC
Primary source
HGNC:HGNC:339
See related
Ensembl:ENSG00000134817 MIM:600052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APJ; APJR; HG11; AGTRL1
Summary
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]
Expression
Biased expression in spleen (RPKM 57.2), placenta (RPKM 39.1) and 11 other tissues See more
Orthologs
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Genomic context

See APLNR in Genome Data Viewer
Location:
11q12.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (57233591..57237250, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57001065..57004904, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369309 Neighboring gene olfactory receptor family 5 subfamily BP member 1 pseudogene Neighboring gene leucine rich repeat containing 55 Neighboring gene Sharpr-MPRA regulatory region 4343 Neighboring gene uncharacterized LOC107984364

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env APJ, a seven transmembrane domain G-protein-coupled receptor, functions as a coreceptor for gp120 from some HIV-1 strains; a natural peptide ligand for APJ, apelin-13, efficiently blocks APJ coreceptor activity PubMed
env Macrophage-tropic HIV-1 can use CCR2b, and to a lesser extent CCR3, STRL33, and APJ, to infect cells; the V1/2 region of HIV-1 gp120 plays a more important role in governing the use of CCR2b, CCR3, STRL33, and APJ than for CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90771, FLJ96609, MGC45246

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables apelin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adult heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in aorta development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apelin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in atrioventricular valve development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in blood vessel development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in coronary vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endocardial cushion formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gastrulation IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heart looping ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cAMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of positive regulation of histone deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of inhibitory G protein-coupled receptor phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of body fluid levels IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of gap junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vascular associated smooth muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in venous blood vessel development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ventricular septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
apelin receptor
Names
APJ (apelin) receptor
APJ receptor
G protein-coupled receptor APJ
G-protein coupled receptor HG11
HG11 orphan receptor
angiotensin II receptor-like 1
angiotensin receptor-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005161.6NP_005152.1  apelin receptor

    See identical proteins and their annotated locations for NP_005152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AP001786
    Consensus CDS
    CCDS7950.1
    UniProtKB/Swiss-Prot
    P35414
    UniProtKB/TrEMBL
    B2RDH3, B3KQN4
    Related
    ENSP00000475344.1, ENST00000606794.1
    Conserved Domains (1) summary
    cd15190
    Location:19320
    7tmA_Apelin_R; apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_027991.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC032688, X89271

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    57233591..57237250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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