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Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B [ Mus musculus (house mouse) ]

Gene ID: 18669, updated on 18-Apr-2019

Summary

Official Symbol
Abcb1bprovided by MGI
Official Full Name
ATP-binding cassette, sub-family B (MDR/TAP), member 1Bprovided by MGI
Primary source
MGI:MGI:97568
See related
Ensembl:ENSMUSG00000028970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mdr; Mdr1; Pgy1; Abcb1; Mdr1b; Pgy-1
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal adult (RPKM 39.4), placenta adult (RPKM 7.7) and 4 other tissues See more
Orthologs

Genomic context

See Abcb1b in Genome Data Viewer
Location:
5 A1; 5 3.43 cM
Exon count:
28
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (8798147..8866314)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (8798147..8866314)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RUN domain containing 3B Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 1A Neighboring gene predicted gene, 31157 Neighboring gene predicted gene 5106 Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 4 Neighboring gene calponin 3, acidic pseudogene Neighboring gene predicted gene, 31388

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
    ABC-family proteins mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Bile secretion, organism-specific biosystem (from KEGG)
    Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Bile secretion, conserved biosystem (from KEGG)
    Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ceramide-translocating ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine-translocating ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylethanolamine-translocating ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Sertoli cell barrier remodeling ISO
Inferred from Sequence Orthology
more info
 
establishment of endothelial blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intercellular canaliculus IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
multidrug resistance protein 1B
Names
ATP-binding cassette sub-family B member 1
P glycoprotein 1
multidrug resistance protein 1
NP_035205.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011075.2NP_035205.1  multidrug resistance protein 1B

    See identical proteins and their annotated locations for NP_035205.1

    Status: VALIDATED

    Source sequence(s)
    AK030328, AK139854, BG080311, BQ829721, BY435708, DV651684
    Consensus CDS
    CCDS19085.1
    UniProtKB/Swiss-Prot
    P06795
    UniProtKB/TrEMBL
    B2RUR3
    Related
    ENSMUSP00000009058.5, ENSMUST00000009058.9
    Conserved Domains (3) summary
    cd03249
    Location:10331272
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:551270
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:54342
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    8798147..8866314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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