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Pgr progesterone receptor [ Mus musculus (house mouse) ]

Gene ID: 18667, updated on 17-Jan-2023

Summary

Official Symbol
Pgrprovided by MGI
Official Full Name
progesterone receptorprovided by MGI
Primary source
MGI:MGI:97567
See related
Ensembl:ENSMUSG00000031870 AllianceGenome:MGI:97567
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PR; PR-A; PR-B; NR3C3; 9930019P03Rik
Summary
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. [provided by RefSeq, Sep 2015]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 5.5), ovary adult (RPKM 4.9) and 6 other tissues See more
Orthologs
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Genomic context

See Pgr in Genome Data Viewer
Location:
9; 9 A1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (8890017..8968612)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (8898900..8968611)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene microRNA 1899 Neighboring gene transient receptor potential cation channel, subfamily C, member 6 Neighboring gene predicted gene, 32014 Neighboring gene Rho GTPase activating protein 42 Neighboring gene predicted gene, 16833 Neighboring gene predicted gene, 51662

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nuclear steroid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear steroid receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within epithelial cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female mating behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glandular epithelial cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of granulosa cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ovulation from ovarian follicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within paracrine signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within progesterone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cocaine ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tertiary branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
progesterone receptor
Names
nuclear receptor subfamily 3 group C member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008829.2NP_032855.2  progesterone receptor

    See identical proteins and their annotated locations for NP_032855.2

    Status: REVIEWED

    Source sequence(s)
    AC113506, AC160964, AK054117, BB149371
    Consensus CDS
    CCDS22816.1
    UniProtKB/Swiss-Prot
    E9QPW3, Q00175
    UniProtKB/TrEMBL
    Q8BW69
    Related
    ENSMUSP00000140124.2, ENSMUST00000189181.7
    Conserved Domains (3) summary
    cd07074
    Location:679926
    NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
    cd07172
    Location:556633
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02161
    Location:1557
    Prog_receptor; Progesterone receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    8890017..8968612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509848.5XP_006509911.1  progesterone receptor isoform X1

    Conserved Domains (2) summary
    pfam02161
    Location:1557
    Prog_receptor; Progesterone receptor
    cl02596
    Location:556589
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers