Pgf placental growth factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pgfprovided by MGI
Official Full Name: placental growth factorprovided by MGI
Primary source: MGI:MGI:105095
See related: Ensembl:ENSMUSG00000004791 AllianceGenome:MGI:105095
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PIGF; Plgf
Summary: Predicted to enable identical protein binding activity; receptor ligand activity; and vascular endothelial growth factor receptor binding activity. Acts upstream of or within branching involved in ureteric bud morphogenesis and regulation of morphogenesis of a branching structure. Located in extracellular space. Is expressed in several structures, including brain; gut gland; musculature; reproductive system; and urinary system. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Orthologous to human PGF (placental growth factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in genital fat pad adult (RPKM 7.3), placenta adult (RPKM 3.2) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D1; 12 39.58 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (85213411..85224559, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (85166637..85177785, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PlGF Reduction Compromises Angiogenesis in Diabetic Foot Disease Through Macrophages.
Title: PlGF Reduction Compromises Angiogenesis in Diabetic Foot Disease Through Macrophages.
Effect of placental growth factor in models of experimental pre-eclampsia and trophoblast invasion.
Title: Effect of placental growth factor in models of experimental pre-eclampsia and trophoblast invasion.
Placental growth factor in beta cells plays an essential role in gestational beta-cell growth.
Title: Placental growth factor in beta cells plays an essential role in gestational beta-cell growth.
Adult Pgf(-/-) mice behaviour and neuroanatomy are altered by neonatal treatment with recombinant placental growth factor.
Title: Adult Pgf(-/-) mice behaviour and neuroanatomy are altered by neonatal treatment with recombinant placental growth factor.
The NFE2L2 (also termed NRF2) transcription factor mediated much of the haem induction of Hmox1 and Hrg1 in all organs, but less so for Pgf.
Title: Cardiac expression of HMOX1 and PGF in sickle cell mice and haem-treated wild type mice dominates organ expression profiles via Nrf2 (Nfe2l2).
Western diet interferes with both baseline expression and hindlimb ischemia-induced upregulation of PLGF. Advanced glycation end product/TNFalpha signaling may function as a negative regulator of PLGF.
Title: Placental growth factor levels in quadriceps muscle are reduced by a Western diet in association with advanced glycation end products.
this study shows that placental growth factor regulates the generation of TH17 cells to link angiogenesis with autoimmunity
Title: Placental growth factor regulates the generation of T(H)17 cells to link angiogenesis with autoimmunity.
These findings provided insights on VEGF-A/PlGF heterodimer function, which was able to rescue neovascularization and vascular leakage.
Title: Full Functional Knockout of Placental Growth Factor by Knockin with an Inactive Variant Able to Heterodimerize with VEGF-A.
ablation of PlGF increases antioxidant and neuroprotective proteins in the diabetic mouse retina
Title: Proteomics reveals ablation of PlGF increases antioxidant and neuroprotective proteins in the diabetic mouse retina.
Lack of placental growth factor (PGF) altered cognitive functions, brain neuroanatomy, and cerebrovasculature in mice.
Title: Effects of placental growth factor deficiency on behavior, neuroanatomy, and cerebrovasculature of mice.

Submit: New GeneRIF Correction See all GeneRIFs (83)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

Pgf (e-PCR), detects polymorphism
- UniSTS:531483

Pgf (e-PCR), detects polymorphism
- UniSTS:144171

Pgf (e-PCR), detects polymorphism
- UniSTS:256826

X96793 (e-PCR)
- UniSTS:185940

Pgf (e-PCR), detects polymorphism
- UniSTS:280405

X80171 (e-PCR)
- UniSTS:125858

RH94485 (e-PCR)
- UniSTS:119733

AI854365 (e-PCR)
- UniSTS:180430

Homology

Homologs of the Pgf gene: The Pgf gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 463 organisms have orthologs with human gene Pgf
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in induction of positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within regulation of morphogenesis of a branching structure	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: placenta growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271705.1 → NP_001258634.1 placenta growth factor isoform 2

See identical proteins and their annotated locations for NP_001258634.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC127582, AK042891

UniProtKB/TrEMBL

Q544A5

Conserved Domains (1) summary

smart00141
Location:1 → 79

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
NM_008827.3 → NP_032853.1 placenta growth factor isoform 1 precursor

See identical proteins and their annotated locations for NP_032853.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). An in-frame AUG is located 4 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.

Source sequence(s)

AC127582, AK042891

Consensus CDS

CCDS49115.1

UniProtKB/Swiss-Prot

P49764

UniProtKB/TrEMBL

Q544A5

Related

ENSMUSP00000004913.7, ENSMUST00000004913.7

Conserved Domains (1) summary

smart00141
Location:46 → 129

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family