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Pgam1 phosphoglycerate mutase 1 [ Mus musculus (house mouse) ]

Gene ID: 18648, updated on 18-Apr-2024

Summary

Official Symbol
Pgam1provided by MGI
Official Full Name
phosphoglycerate mutase 1provided by MGI
Primary source
MGI:MGI:97552
See related
Ensembl:ENSMUSG00000011752 AllianceGenome:MGI:97552
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pgam-1; 2310050F24Rik
Summary
Enables phosphoglycerate mutase activity. Predicted to act upstream of or within glycolytic process. Located in myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to several human genes including PGAM1 (phosphoglycerate mutase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 262.8), kidney adult (RPKM 216.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
19 C3; 19 35.44 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41900310..41907104)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41911871..41918665)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ribosomal RNA processing 12 homolog Neighboring gene STARR-positive B cell enhancer ABC_E4281 Neighboring gene predicted gene, 46644 Neighboring gene STARR-positive B cell enhancer ABC_E7659 Neighboring gene exosome component 1 Neighboring gene STARR-positive B cell enhancer ABC_E3252 Neighboring gene zinc finger, DHHC domain containing 16 Neighboring gene MMS19 cytosolic iron-sulfur assembly component

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102422, MGC118049

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity ISO
Inferred from Sequence Orthology
more info
 
enables bisphosphoglycerate mutase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables intramolecular phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoglycerate mutase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoglycerate mutase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glyceraldehyde-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphoglycerate mutase 1
Names
BPG-dependent PGAM 1
PGAM-B
phosphoglycerate mutase isozyme B
NP_075907.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023418.2NP_075907.2  phosphoglycerate mutase 1

    See identical proteins and their annotated locations for NP_075907.2

    Status: VALIDATED

    Source sequence(s)
    AC140193, AK159305, BP769634
    Consensus CDS
    CCDS29815.1
    UniProtKB/Swiss-Prot
    Q9D6W0, Q9DBJ1, Q9ERT3
    UniProtKB/TrEMBL
    Q3U7Z6
    Related
    ENSMUSP00000011896.7, ENSMUST00000011896.8
    Conserved Domains (1) summary
    PRK14115
    Location:4253
    gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    41900310..41907104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)