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Cdk14 cyclin dependent kinase 14 [ Mus musculus (house mouse) ]

Gene ID: 18647, updated on 21-May-2024

Summary

Official Symbol
Cdk14provided by MGI
Official Full Name
cyclin dependent kinase 14provided by MGI
Primary source
MGI:MGI:894318
See related
Ensembl:ENSMUSG00000028926 AllianceGenome:MGI:894318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pftk1; mKIAA0834
Summary
Enables protein kinase activity. Predicted to be involved in mitotic cell cycle phase transition; protein phosphorylation; and regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway; cell division; and phosphorylation. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human CDK14 (cyclin dependent kinase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 18.7), cortex adult (RPKM 14.0) and 13 other tissues See more
Orthologs
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Genomic context

See Cdk14 in Genome Data Viewer
Location:
5 A1; 5 2.61 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (4853384..5430650, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (4803384..5380251, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12336 Neighboring gene predicted gene, 54299 Neighboring gene STARR-seq mESC enhancer starr_12337 Neighboring gene frizzled class receptor 1 Neighboring gene STARR-seq mESC enhancer starr_12338 Neighboring gene VISTA enhancer mm49 Neighboring gene predicted gene, 22897 Neighboring gene predicted gene, 54300 Neighboring gene STARR-seq mESC enhancer starr_12339 Neighboring gene STARR-seq mESC enhancer starr_12340 Neighboring gene STARR-seq mESC enhancer starr_12341 Neighboring gene STARR-seq mESC enhancer starr_12342 Neighboring gene predicted gene, 30151 Neighboring gene STARR-seq mESC enhancer starr_12343 Neighboring gene PTTG1IP family member 2 Neighboring gene predicted gene, 30325

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 14
Names
cell division protein kinase 14
serine/threonine-protein kinase PFTAIRE-1
NP_001297377.1
NP_001411391.1
NP_001411392.1
NP_001411393.1
NP_001411394.1
NP_001411395.1
NP_035204.2
XP_017176197.1
XP_036020764.1
XP_036020765.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310448.2NP_001297377.1  cyclin-dependent kinase 14 isoform 2

    See identical proteins and their annotated locations for NP_001297377.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC026231, AC026233, AC044805, AC068140
    Consensus CDS
    CCDS80203.1
    UniProtKB/TrEMBL
    Q6NVF8, Q8C411
    Related
    ENSMUSP00000111111.2, ENSMUST00000115451.8
    Conserved Domains (1) summary
    cd07869
    Location:83385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
  2. NM_001424462.1NP_001411391.1  cyclin-dependent kinase 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC026231, AC026233, AC044805, AC068140
    UniProtKB/TrEMBL
    Q6NVF8
    Related
    ENSMUSP00000111110.2, ENSMUST00000115450.8
  3. NM_001424463.1NP_001411392.1  cyclin-dependent kinase 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC026231, AC026232, AC026233, AC044805, AC068140
    UniProtKB/TrEMBL
    Q6NVF8
  4. NM_001424464.1NP_001411393.1  cyclin-dependent kinase 14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC026231, AC026233, AC044805, AC068140
  5. NM_001424465.1NP_001411394.1  cyclin-dependent kinase 14 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC026231, AC026233, AC044805, AC068140
    UniProtKB/TrEMBL
    E9PVC7
    Related
    ENSMUSP00000111112.2, ENSMUST00000115452.8
  6. NM_001424466.1NP_001411395.1  cyclin-dependent kinase 14 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC026231, AC026233, AC044805, AC068140, AC068663
  7. NM_011074.4NP_035204.2  cyclin-dependent kinase 14 isoform 1

    See identical proteins and their annotated locations for NP_035204.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC026231, AC026233, AC044805, AC068140, AC068663
    Consensus CDS
    CCDS19073.1
    UniProtKB/Swiss-Prot
    O35495, O35848, Q3TNN9, Q3V319, Q6ZQ37
    Related
    ENSMUSP00000030763.7, ENSMUST00000030763.13
    Conserved Domains (2) summary
    cd07869
    Location:129431
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
    PLN00009
    Location:133422
    PLN00009; cyclin-dependent kinase A; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    4853384..5430650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164871.1XP_036020764.1  cyclin-dependent kinase 14 isoform X2

    Conserved Domains (1) summary
    cd07869
    Location:95397
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
  2. XM_036164872.1XP_036020765.1  cyclin-dependent kinase 14 isoform X3

    UniProtKB/TrEMBL
    Q6NVF8, Q8C411
    Conserved Domains (1) summary
    cd07869
    Location:83385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
  3. XM_017320708.1XP_017176197.1  cyclin-dependent kinase 14 isoform X3

    UniProtKB/TrEMBL
    Q6NVF8, Q8C411
    Conserved Domains (1) summary
    cd07869
    Location:83385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase