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Cdk14 cyclin-dependent kinase 14 [ Mus musculus (house mouse) ]

Gene ID: 18647, updated on 2-Oct-2022

Summary

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Official Symbol
Cdk14provided by MGI
Official Full Name
cyclin-dependent kinase 14provided by MGI
Primary source
MGI:MGI:894318
See related
Ensembl:ENSMUSG00000028926 AllianceGenome:MGI:894318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pftk1; mKIAA0834
Summary
Enables protein kinase activity. Predicted to be involved in mitotic cell cycle phase transition; protein phosphorylation; and regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway; cell division; and phosphorylation. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human CDK14 (cyclin dependent kinase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 18.7), cortex adult (RPKM 14.0) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Cdk14 in Genome Data Viewer
Location:
5 A1; 5 2.61 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (4853384..5430251, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (4803384..5380251, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54299 Neighboring gene frizzled class receptor 1 Neighboring gene VISTA enhancer mm49 Neighboring gene predicted gene, 22897 Neighboring gene predicted gene, 54300 Neighboring gene predicted gene, 30151 Neighboring gene PTTG1IP family member 2 Neighboring gene predicted gene, 30325

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression. Zhang M, et al. Cell Rep, 2022 Sep 13. PMID 36103813
  2. CDK14 expression is down-regulated by cigarette smoke in vivo and in vitro. Pollack D, et al. Toxicol Lett, 2015 Apr 16. PMID 25680692, Free PMC Article
  3. A novel TRH-PFTAIRE protein kinase 1 pathway in the cerebellum: subtractive hybridization analysis of TRH-deficient mice. Hashida T, et al. Endocrinology, 2002 Jul. PMID 12072416
  4. Chromosomal mapping of the PFTAIRE gene, Pftk1, a cdc2-related kinase expressed predominantly in the mouse nervous system. Lazzaro MA, et al. Genomics, 1997 Jun 15. PMID 9205131
  5. [Phosphorus-calcium metabolism in children under long-term anticonvulsant therapy]. Lluch Fernández MD, et al. An Esp Pediatr, 1991 Aug. PMID 1952457

See all (32) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression.
    Title: CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression.
  2. Cigarette smoke down regulates CDK14 levels and impairs Wnt signaling.
    Title: CDK14 expression is down-regulated by cigarette smoke in vivo and in vitro.
  3. may be a key regulator for thyrotropin-releasing hormone (TRH) action in the cerebellum through the NO-cGMP pathway
    Title: A novel TRH-PFTAIRE protein kinase 1 pathway in the cerebellum: subtractive hybridization analysis of TRH-deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription involved in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 14
Names
cell division protein kinase 14
serine/threonine-protein kinase PFTAIRE-1
NP_001297377.1
NP_035204.2
XP_006503607.1
XP_006503610.1
XP_017176197.1
XP_036020764.1
XP_036020765.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310448.1 → NP_001297377.1  cyclin-dependent kinase 14 isoform 2

    See identical proteins and their annotated locations for NP_001297377.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK138437, AK139386, BC068134, BE948428
    Consensus CDS
    CCDS80203.1
    UniProtKB/TrEMBL
    Q6NVF8
    Related
    ENSMUSP00000111111.2, ENSMUST00000115451.8
    Conserved Domains (1) summary
    cd07869
    Location:83 → 385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

  2. NM_011074.3 → NP_035204.2  cyclin-dependent kinase 14 isoform 1

    See identical proteins and their annotated locations for NP_035204.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK045083, AK051283, AK139386, BC068134, BE948428
    Consensus CDS
    CCDS19073.1
    UniProtKB/Swiss-Prot
    O35495, Q6ZQ37
    UniProtKB/TrEMBL
    Q6NVF8, Q8BFX6
    Related
    ENSMUSP00000030763.7, ENSMUST00000030763.13
    Conserved Domains (2) summary
    cd07869
    Location:129 → 431
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
    PLN00009
    Location:133 → 422
    PLN00009; cyclin-dependent kinase A; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    4853384..5430251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503544.5 → XP_006503607.1  cyclin-dependent kinase 14 isoform X1

    Related
    ENSMUSP00000111112.2, ENSMUST00000115452.8
    Conserved Domains (1) summary
    cd07869
    Location:137 → 439
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

  2. XM_006503547.5 → XP_006503610.1  cyclin-dependent kinase 14 isoform X3

    See identical proteins and their annotated locations for XP_006503610.1

    UniProtKB/TrEMBL
    Q6NVF8
    Related
    ENSMUSP00000111110.2, ENSMUST00000115450.8
    Conserved Domains (1) summary
    cd07869
    Location:83 → 385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

  3. XM_036164871.1 → XP_036020764.1  cyclin-dependent kinase 14 isoform X2

    Conserved Domains (1) summary
    cd07869
    Location:95 → 397
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

  4. XM_036164872.1 → XP_036020765.1  cyclin-dependent kinase 14 isoform X3

    UniProtKB/TrEMBL
    Q6NVF8
    Conserved Domains (1) summary
    cd07869
    Location:83 → 385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

  5. XM_017320708.1 → XP_017176197.1  cyclin-dependent kinase 14 isoform X3

    UniProtKB/TrEMBL
    Q6NVF8
    Conserved Domains (1) summary
    cd07869
    Location:83 → 385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35495.2 GenPept UniProtKB/Swiss-Prot:O35495

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