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Pfn2 profilin 2 [ Mus musculus (house mouse) ]

Gene ID: 18645, updated on 9-Dec-2024

Summary

Official Symbol
Pfn2provided by MGI
Official Full Name
profilin 2provided by MGI
Primary source
MGI:MGI:97550
See related
Ensembl:ENSMUSG00000027805 AllianceGenome:MGI:97550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pfn
Summary
Predicted to enable actin monomer binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including negative regulation of ruffle assembly; positive regulation of stress fiber assembly; and synapse organization. Acts upstream of or within positive regulation of actin filament polymerization and regulation of synaptic vesicle exocytosis. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Is expressed in several structures, including central nervous system; cornea stroma; ganglia; hemolymphoid system gland; and tooth. Orthologous to human PFN2 (profilin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in CNS E18 (RPKM 159.8), whole brain E14.5 (RPKM 144.6) and 13 other tissues See more
Orthologs
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Genomic context

See Pfn2 in Genome Data Viewer
Location:
3 D; 3 28.15 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (57749316..57755178, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (57841895..57847757, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 13 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07740 Neighboring gene predicted gene, 32753 Neighboring gene predicted gene, 40055 Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07741 Neighboring gene STARR-seq mESC enhancer starr_07742 Neighboring gene predicted gene, 40056 Neighboring gene predicted gene 5537

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
 
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in modification of postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modification of postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ruffle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic actin cytoskeleton organization EXP
Inferred from Experiment
more info
PubMed 
involved_in presynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
profilin-2
Names
profilin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019410.3NP_062283.1  profilin-2

    See identical proteins and their annotated locations for NP_062283.1

    Status: VALIDATED

    Source sequence(s)
    AC165888, AK132651
    Consensus CDS
    CCDS17364.1
    UniProtKB/Swiss-Prot
    Q3TPT7, Q3V171, Q9ES48, Q9ES49, Q9ES50, Q9JJV2
    Related
    ENSMUSP00000068890.9, ENSMUST00000066882.10
    Conserved Domains (1) summary
    smart00392
    Location:2140
    PROF; Profilin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    57749316..57755178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)