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Per1 period circadian clock 1 [ Mus musculus (house mouse) ]

Gene ID: 18626, updated on 3-Jun-2024

Summary

Official Symbol
Per1provided by MGI
Official Full Name
period circadian clock 1provided by MGI
Primary source
MGI:MGI:1098283
See related
Ensembl:ENSMUSG00000020893 AllianceGenome:MGI:1098283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Per; Hftm; mPer1; m-rigui
Summary
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in testis adult (RPKM 28.8), adrenal adult (RPKM 16.3) and 25 other tissues See more
Orthologs
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Genomic context

See Per1 in Genome Data Viewer
Location:
11 B3; 11 42.37 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68985934..69000791)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69095108..69109965)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68887007-68887116 Neighboring gene small nucleolar RNA, C/D box 118 Neighboring gene vesicle-associated membrane protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E7003 Neighboring gene STARR-positive B cell enhancer ABC_E197 Neighboring gene STARR-positive B cell enhancer ABC_E733 Neighboring gene STARR-positive B cell enhancer ABC_E8417 Neighboring gene nuclear encoded tRNA threonine 5 (anticodon AGT) Neighboring gene nuclear encoded tRNA serine 14 (anticodon CGA)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102121

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within circadian rhythm TAS
Traceable Author Statement
more info
PubMed 
involved_in entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucocorticoid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of hair cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
period circadian protein homolog 1
Names
circadian clock protein PERIOD 1
circadian pacemaker protein Rigui
period homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159367.2NP_001152839.1  period circadian protein homolog 1

    See identical proteins and their annotated locations for NP_001152839.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF022992, AK148202, BC091645, BP772916
    Consensus CDS
    CCDS24882.1
    UniProtKB/Swiss-Prot
    B1ASX0, O35973
    UniProtKB/TrEMBL
    Q3UFZ7
    Related
    ENSMUSP00000132635.2, ENSMUST00000166748.8
    Conserved Domains (3) summary
    pfam08447
    Location:373457
    PAS_3; PAS fold
    pfam12114
    Location:10821223
    Period_C; Period protein 2/3C-terminal region
    pfam15761
    Location:659
    IMUP; Immortalisation up-regulated protein
  2. NM_011065.5NP_035195.2  period circadian protein homolog 1

    See identical proteins and their annotated locations for NP_035195.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF022992, BC091645, BP772916
    Consensus CDS
    CCDS24882.1
    UniProtKB/Swiss-Prot
    B1ASX0, O35973
    UniProtKB/TrEMBL
    Q3UFZ7
    Related
    ENSMUSP00000021271.8, ENSMUST00000021271.14
    Conserved Domains (3) summary
    pfam08447
    Location:373457
    PAS_3; PAS fold
    pfam12114
    Location:10821223
    Period_C; Period protein 2/3C-terminal region
    pfam15761
    Location:659
    IMUP; Immortalisation up-regulated protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    68985934..69000791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532480.4XP_006532543.1  period circadian protein homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006532543.1

    UniProtKB/Swiss-Prot
    B1ASX0, O35973
    UniProtKB/TrEMBL
    Q3UFZ7
    Conserved Domains (3) summary
    pfam08447
    Location:373457
    PAS_3; PAS fold
    pfam12114
    Location:10821223
    Period_C; Period protein 2/3C-terminal region
    pfam15761
    Location:659
    IMUP; Immortalisation up-regulated protein
  2. XM_030245657.2XP_030101517.1  period circadian protein homolog 1 isoform X2

    UniProtKB/TrEMBL
    Q3UFZ7
    Conserved Domains (3) summary
    pfam08447
    Location:373457
    PAS_3; PAS fold
    pfam12114
    Location:10781219
    Period_C; Period protein 2/3C-terminal region
    pfam15761
    Location:659
    IMUP; Immortalisation up-regulated protein
  3. XM_036156420.1XP_036012313.1  period circadian protein homolog 1 isoform X3

    UniProtKB/TrEMBL
    Q3UFZ7
    Conserved Domains (3) summary
    pfam08447
    Location:373457
    PAS_3; PAS fold
    pfam12114
    Location:10511154
    Period_C; Period protein 2/3C-terminal region
    NF033845
    Location:8137
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
  4. XM_006532481.5XP_006532544.1  period circadian protein homolog 1 isoform X2

    UniProtKB/TrEMBL
    Q3UFZ7
    Conserved Domains (3) summary
    pfam08447
    Location:373457
    PAS_3; PAS fold
    pfam12114
    Location:10781219
    Period_C; Period protein 2/3C-terminal region
    pfam15761
    Location:659
    IMUP; Immortalisation up-regulated protein
  5. XM_036156421.1XP_036012314.1  period circadian protein homolog 1 isoform X4

    UniProtKB/TrEMBL
    Q3UFZ7
    Conserved Domains (3) summary
    pfam08447
    Location:373457
    PAS_3; PAS fold
    pfam12114
    Location:10221163
    Period_C; Period protein 2/3C-terminal region
    NF033845
    Location:13137
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB