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F53H8.3 Major facilitator superfamily (MFS) profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 186195, updated on 4-Jan-2025

Summary

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Official Symbol
F53H8.3
Official Full Name
Major facilitator superfamily (MFS) profile domain-containing protein
Primary source
WormBase:WBGene00018779
Locus tag
CELE_F53H8.3
See related
AllianceGenome:WB:WBGene00018779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in monosaccharide transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including E; Ea; Eal; Eala; and intestinal cell. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose metabolism disease (multiple); glycogen storage disease; myelomeningocele; and obesity. Orthologous to human SLC2A1 (solute carrier family 2 member 1); SLC2A2 (solute carrier family 2 member 2); and SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F53H8.3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (938543..942609)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Rab GTPase-activating protein tbc-11 Neighboring gene Schwannomin interacting protein 1 C-terminal domain-containing protein Neighboring gene Phosphatidylcholine:ceramide cholinephosphotransferase 2 Neighboring gene Beta-arrestin arr-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hexose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hexose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monosaccharide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Major facilitator superfamily (MFS) profile domain-containing protein
NP_001359933.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    938543..942609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373218.2 → NP_001359933.1  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20734
    Conserved Domains (1) summary
    cd17357
    Location:9 → 454
    MFS_GLUT_Class1_2_like; Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
Nucleotide Protein
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