U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

apm-3 MHD domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 186194, updated on 23-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
apm-3
Gene description
MHD domain-containing protein
Primary source
WormBase:WBGene00000164
Locus tag
CELE_F53H8.1
See related
AllianceGenome:WB:WBGene00000164
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in lipid storage and lysosome organization. Predicted to be located in membrane. Predicted to be part of clathrin adaptor complex. Predicted to be active in cytoplasmic vesicle. Is expressed in several structures, including muscle cell; nervous system; pharynx; spermatheca; and vulva. Orthologous to several human genes including AP3M1 (adaptor related protein complex 3 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (954975..957762)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Phosphatidylcholine:ceramide cholinephosphotransferase 2 Neighboring gene Beta-arrestin arr-1 Neighboring gene GH18 domain-containing protein Neighboring gene Neuronal calcium sensor 1 Neighboring gene Neuropeptide-Like Protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. miR-51 regulates GABAergic synapses by targeting Rab GEF GLO-4 and lysosomal trafficking-related GLO/AP-3 pathway in Caenorhabditis elegans. Zhang S, et al. Dev Biol, 2018 Apr 1. PMID 29476722
  2. The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans. Shim J, et al. Mol Cells, 2005 Jun 30. PMID 15995364
  3. Widespread organisation of C. elegans genes into operons: fact or function? Nimmo R, et al. Bioessays, 2002 Nov. PMID 12386927
  4. Role of the Caenorhabditis elegans multidrug resistance gene, mrp-4, in gut granule differentiation. Currie E, et al. Genetics, 2007 Nov. PMID 17947407, Free PMC Article
  5. C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1. Grill B, et al. Neuron, 2007 Aug 16. PMID 17698012

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lysosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
MHD domain-containing protein
NP_508184.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    954975..957762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075783.7 → NP_508184.2  MHD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508184.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20736
    Conserved Domains (2) summary
    cd09252
    Location:165 → 413
    AP-3_Mu3_Cterm; C-terminal domain of medium Mu3 subunit in adaptor protein (AP) complex AP-3
    cd14837
    Location:3 → 141
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous