U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Penk preproenkephalin [ Mus musculus (house mouse) ]

Gene ID: 18619, updated on 28-Mar-2023

Summary

Official Symbol
Penkprovided by MGI
Official Full Name
preproenkephalinprovided by MGI
Primary source
MGI:MGI:104629
See related
Ensembl:ENSMUSG00000045573 AllianceGenome:MGI:104629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ENK; PPA; Penk1
Summary
Predicted to enable opioid receptor binding activity. Acts upstream of or within several processes, including behavioral fear response; sensory perception of pain; and startle response. Predicted to be located in several cellular components, including cell body fiber; perikaryon; and symmetric synapse. Predicted to be active in several cellular components, including axon terminus; dendrite; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PENK (proenkephalin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 34.5), frontal lobe adult (RPKM 32.9) and 16 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Penk in Genome Data Viewer
Location:
4 A1; 4 2.31 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (4133536..4138815, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (4133536..4138815, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 16C, member 5 Neighboring gene predicted gene, 52721 Neighboring gene short chain dehydrogenase/reductase family 16C, member 6 Neighboring gene RIKEN cDNA A830012C17 gene Neighboring gene predicted gene, 33007

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables opioid peptide activity IDA
Inferred from Direct Assay
more info
PubMed 
enables opioid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables opioid receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cell body fiber ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal dense core vesicle lumen ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in symmetric synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle lumen ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proenkephalin-A
Names
preproenkephalin 1
spermatogenic-specific proenkephalin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002927.3NP_001002927.1  proenkephalin-A precursor

    See identical proteins and their annotated locations for NP_001002927.1

    Status: VALIDATED

    Source sequence(s)
    BC049766, CX236539
    Consensus CDS
    CCDS17946.1
    UniProtKB/Swiss-Prot
    P22005, Q68G73
    Related
    ENSMUSP00000066822.8, ENSMUST00000070375.8
    Conserved Domains (1) summary
    pfam01160
    Location:2570
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  2. NM_001348209.1NP_001335138.1  proenkephalin-A precursor

    Status: VALIDATED

    Source sequence(s)
    AK135111, AK161272, CX236539
    Consensus CDS
    CCDS17946.1
    UniProtKB/Swiss-Prot
    P22005, Q68G73
    UniProtKB/TrEMBL
    Q3UXY8
    Conserved Domains (1) summary
    pfam01160
    Location:2570
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    4133536..4138815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)