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Etv4 ets variant 4 [ Mus musculus (house mouse) ]

Gene ID: 18612, updated on 31-Jan-2023

Summary

Official Symbol
Etv4provided by MGI
Official Full Name
ets variant 4provided by MGI
Primary source
MGI:MGI:99423
See related
Ensembl:ENSMUSG00000017724 AllianceGenome:MGI:99423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pea3; Pea-3
Summary
Enables DNA binding activity. Involved in positive regulation of gene expression. Acts upstream of or within several processes, including branching involved in mammary gland duct morphogenesis; motor neuron axon guidance; and negative regulation of mammary gland epithelial cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; sensory organ; and urinary system. Orthologous to human ETV4 (ETS variant transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 15.6), colon adult (RPKM 7.7) and 13 other tissues See more
Orthologs
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Genomic context

See Etv4 in Genome Data Viewer
Location:
11 D; 11 65.48 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101660573..101677963, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101769747..101785310, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39391 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 8 Neighboring gene predicted gene, 39392 Neighboring gene mesenchyme homeobox 1 Neighboring gene predicted gene, 33662

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ETS translocation variant 4
Names
ETS variant protein 4
POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3 PROTEIN) (ETS TRANSLOCATION VARIANT 4)
ets variant gene 4 (E1A enhancer binding protein, E1AF)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316365.1NP_001303294.1  ETS translocation variant 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK144538, AL591436, BY733846, DQ832277
    Consensus CDS
    CCDS83903.1
    UniProtKB/TrEMBL
    A2A5C3, A6MDC6
    Related
    ENSMUSP00000017868.7, ENSMUST00000017868.7
    Conserved Domains (2) summary
    smart00413
    Location:343426
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:7341
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  2. NM_001316366.1NP_001303295.1  ETS translocation variant 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK144538, AL591436, DQ832277
    Consensus CDS
    CCDS83902.1
    UniProtKB/TrEMBL
    A2A5C2, A6MDC6
    Related
    ENSMUSP00000102794.2, ENSMUST00000107176.8
    Conserved Domains (2) summary
    smart00413
    Location:337420
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:7335
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  3. NM_008815.3NP_032841.2  ETS translocation variant 4 isoform 2

    See identical proteins and their annotated locations for NP_032841.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK144538, AL591436, DQ832277
    Consensus CDS
    CCDS48937.1
    UniProtKB/Swiss-Prot
    P28322, Q3UMZ6
    UniProtKB/TrEMBL
    A6MDC6
    Related
    ENSMUSP00000129261.2, ENSMUST00000164750.8
    Conserved Domains (2) summary
    smart00413
    Location:342425
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:7340
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101660573..101677963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245656.2XP_030101516.1  ETS translocation variant 4 isoform X7

    Conserved Domains (2) summary
    smart00413
    Location:338421
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:8336
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  2. XM_006532462.5XP_006532525.1  ETS translocation variant 4 isoform X5

    Conserved Domains (2) summary
    smart00413
    Location:344427
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:8342
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  3. XM_006532461.4XP_006532524.1  ETS translocation variant 4 isoform X4

    Conserved Domains (2) summary
    smart00413
    Location:383466
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:54381
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  4. XM_006532459.4XP_006532522.1  ETS translocation variant 4 isoform X2

    Conserved Domains (2) summary
    smart00413
    Location:389472
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:54387
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  5. XM_006532460.4XP_006532523.1  ETS translocation variant 4 isoform X3

    Conserved Domains (2) summary
    smart00413
    Location:384467
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:54382
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  6. XM_006532458.4XP_006532521.1  ETS translocation variant 4 isoform X1

    Conserved Domains (2) summary
    smart00413
    Location:390473
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:54388
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  7. XM_036156416.1XP_036012309.1  ETS translocation variant 4 isoform X6

    UniProtKB/TrEMBL
    A2A5C3
    Conserved Domains (2) summary
    smart00413
    Location:343426
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:7341
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  8. XM_036156418.1XP_036012311.1  ETS translocation variant 4 isoform X8

    UniProtKB/TrEMBL
    A2A5C2
    Conserved Domains (2) summary
    smart00413
    Location:337420
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:7335
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  9. XM_036156419.1XP_036012312.1  ETS translocation variant 4 isoform X8

    UniProtKB/TrEMBL
    A2A5C2
    Conserved Domains (2) summary
    smart00413
    Location:337420
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:7335
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  10. XM_036156417.1XP_036012310.1  ETS translocation variant 4 isoform X6

    UniProtKB/TrEMBL
    A2A5C3
    Conserved Domains (2) summary
    smart00413
    Location:343426
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:7341
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain