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AGTR2 angiotensin II receptor type 2 [ Homo sapiens (human) ]

Gene ID: 186, updated on 2-Mar-2021

Summary

Official Symbol
AGTR2provided by HGNC
Official Full Name
angiotensin II receptor type 2provided by HGNC
Primary source
HGNC:HGNC:338
See related
Ensembl:ENSG00000180772 MIM:300034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AT2; ATGR2; MRX88
Summary
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients. [provided by RefSeq, Jul 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression
Biased expression in lung (RPKM 5.8), endometrium (RPKM 4.4) and 2 other tissues See more
Orthologs
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Genomic context

See AGTR2 in Genome Data Viewer
Location:
Xq23
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (116170744..116174974)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (115301997..115306227)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1 member B1 pseudogene 8 Neighboring gene apoptosis inhibitor 5 pseudogene 1 Neighboring gene RNA, U6 small nuclear 154, pseudogene Neighboring gene solute carrier family 6 member 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.
GeneReviews: Not available

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-05-10)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-05-10)

ClinGen Genome Curation Page

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiotensin type II receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiotensin type II receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor antagonist activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
aldosterone secretion IEA
Inferred from Electronic Annotation
more info
 
angiotensin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling TAS
Traceable Author Statement
more info
PubMed 
brain development NAS
Non-traceable Author Statement
more info
PubMed 
cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular sodium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cerebellar cortex development IEA
Inferred from Electronic Annotation
more info
 
dopamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
kidney morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood vessel endothelial cell migration NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of icosanoid secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neurotrophin TRK receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of norepinephrine secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
nitric oxide mediated signal transduction IC
Inferred by Curator
more info
PubMed 
nitric oxide mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IC
Inferred by Curator
more info
PubMed 
positive regulation of nitric-oxide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure by circulatory renin-angiotensin ISS
Inferred from Sequence or Structural Similarity
more info
 
renin-angiotensin regulation of aldosterone production IEA
Inferred from Electronic Annotation
more info
 
vasodilation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
type-2 angiotensin II receptor
Names
angiotensin II type-2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016326.1 RefSeqGene

    Range
    5040..9270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000686.5NP_000677.2  type-2 angiotensin II receptor isoform 1

    See identical proteins and their annotated locations for NP_000677.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI911273, AL732602, BC095504, CR738498, DA538369, U16957
    Consensus CDS
    CCDS14569.1
    UniProtKB/Swiss-Prot
    P50052
    Related
    ENSP00000360973.4, ENST00000371906.5
    Conserved Domains (1) summary
    cd15191
    Location:45329
    7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001385624.1NP_001372553.1  type-2 angiotensin II receptor isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the non-coding region compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL732602
    Related
    ENSP00000505750.1, ENST00000681852.1
    Conserved Domains (1) summary
    cd15191
    Location:45329
    7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    116170744..116174974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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