AGTR2 angiotensin II receptor type 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: AGTR2provided by HGNC
Official Full Name: angiotensin II receptor type 2provided by HGNC
Primary source: HGNC:HGNC:338
See related: Ensembl:ENSG00000180772 MIM:300034; AllianceGenome:HGNC:338
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AT2; ATGR2; MRX88
Summary: The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients. [provided by RefSeq, Jul 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression: Biased expression in lung (RPKM 5.8), endometrium (RPKM 4.4) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq23

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (116170744..116174974)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (114580328..114584558)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (115301997..115306227)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Angiotensin II type 2 receptor prevents extracellular matrix accumulation in human peritoneal mesothelial cell by ameliorating lipid disorder via LOX-1 suppression.
Title: Angiotensin II type 2 receptor prevents extracellular matrix accumulation in human peritoneal mesothelial cell by ameliorating lipid disorder via LOX-1 suppression.
The Role of ACE, ACE2, and AGTR2 Polymorphisms in COVID-19 Severity and the Presence of COVID-19-Related Retinopathy.
Title: The Role of ACE, ACE2, and AGTR2 Polymorphisms in COVID-19 Severity and the Presence of COVID-19-Related Retinopathy.
Exploring AT2R and its Polymorphism in Different Diseases: An Approach to Develop AT2R as a Drug Target beyond Hypertension.
Title: Exploring AT2R and its Polymorphism in Different Diseases: An Approach to Develop AT2R as a Drug Target beyond Hypertension.
AT2R activation increases in vitro angiogenesis in pregnant human uterine artery endothelial cells.
Title: AT2R activation increases in vitro angiogenesis in pregnant human uterine artery endothelial cells.
Association of maternal angiotensin II type 1 and type 2 receptor combination genotypes with susceptibility to early-onset preeclampsia.
Title: Association of maternal angiotensin II type 1 and type 2 receptor combination genotypes with susceptibility to early-onset preeclampsia.
Colon adenocarcinoma-derived cells possessing stem cell function can be modulated using renin-angiotensin system inhibitors.
Title: Colon adenocarcinoma-derived cells possessing stem cell function can be modulated using renin-angiotensin system inhibitors.
GABA is a mediator of brain AT1 and AT2 receptor-mediated blood pressure responses.
Title: GABA is a mediator of brain AT<sub>1</sub> and AT<sub>2</sub> receptor-mediated blood pressure responses.
AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells.
Title: AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells.
Variants in AGTR2 gene in Maya people with COVID-19.
Title: Variants in AGTR2 gene in Maya people with COVID-19.
Preoperative angiotensin II type 2 receptor is a predictor for developing chronic post-surgical pain after total knee arthroplasty surgery.
Title: Preoperative angiotensin II type 2 receptor is a predictor for developing chronic post-surgical pain after total knee arthroplasty surgery.

Submit: New GeneRIF Correction See all GeneRIFs (165)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2012-05-10) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2012-05-10) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AGTR2 (e-PCR)
- UniSTS:498204

GDB:360300 (e-PCR)
- UniSTS:156714

AGTR2__4208 (e-PCR)
- UniSTS:462720

PMC153509P1 (e-PCR)
- UniSTS:271257

STS-U20860 (e-PCR)
- UniSTS:28413

Homology

Homologs of the AGTR2 gene: The AGTR2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 400 organisms have orthologs with human gene AGTR2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables angiotensin type II receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables angiotensin type II receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables angiotensin type II receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor antagonist activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IC Inferred by Curator more info	PubMed
involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in angiotensin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in blood vessel remodeling	TAS Traceable Author Statement more info	PubMed
involved_in brain development	NAS Non-traceable Author Statement more info	PubMed
involved_in brain renin-angiotensin system	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in exploration behavior	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of blood vessel endothelial cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of cell growth	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of heart rate	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neurotrophin TRK receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of signaling receptor activity	IEA Inferred from Electronic Annotation more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide mediated signal transduction	IC Inferred by Curator more info	PubMed
involved_in nitric oxide mediated signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of metanephric glomerulus development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	IC Inferred by Curator more info	PubMed
involved_in positive regulation of nitric-oxide synthase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood pressure	TAS Traceable Author Statement more info	PubMed
involved_in regulation of metanephros size	IEA Inferred from Electronic Annotation more info
involved_in regulation of systemic arterial blood pressure by circulatory renin-angiotensin	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasodilation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: type-2 angiotensin II receptor

Names: AT2 receptor; angiotensin II type-2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016326.1 RefSeqGene

Range

5040..9270

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000686.5 → NP_000677.2 type-2 angiotensin II receptor isoform 1

See identical proteins and their annotated locations for NP_000677.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AI911273, AL732602, BC095504, CR738498, DA538369, U16957

Consensus CDS

CCDS14569.1

UniProtKB/Swiss-Prot

P50052, Q6FGY7

Related

ENSP00000360973.4, ENST00000371906.5

Conserved Domains (1) summary

cd15191
Location:45 → 329

7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001385624.1 → NP_001372553.1 type-2 angiotensin II receptor isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the non-coding region compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL732602

Consensus CDS

CCDS14569.1

UniProtKB/Swiss-Prot

Q6FGY7

Related

ENSP00000505750.1, ENST00000681852.1

Conserved Domains (1) summary

cd15191
Location:45 → 329

7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors