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AGTR2 angiotensin II receptor type 2 [ Homo sapiens (human) ]

Gene ID: 186, updated on 18-Nov-2019

Summary

Official Symbol
AGTR2provided by HGNC
Official Full Name
angiotensin II receptor type 2provided by HGNC
Primary source
HGNC:HGNC:338
See related
Ensembl:ENSG00000180772 MIM:300034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AT2; ATGR2; MRX88
Summary
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. [provided by RefSeq, Jan 2010]
Expression
Biased expression in lung (RPKM 5.8), endometrium (RPKM 4.4) and 2 other tissues See more
Orthologs

Genomic context

See AGTR2 in Genome Data Viewer
Location:
Xq23
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (116170744..116174974)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (115301958..115306225)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1 member B1 pseudogene 8 Neighboring gene apoptosis inhibitor 5 pseudogene 1 Neighboring gene RNA, U6 small nuclear 154, pseudogene Neighboring gene solute carrier family 6 member 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-05-10)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-05-10)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.
NHGRI GWA Catalog

Pathways from BioSystems

  • ACE Inhibitor Pathway, organism-specific biosystem (from WikiPathways)
    ACE Inhibitor Pathway, organism-specific biosystemThe core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by an...
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiotensin type II receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiotensin type II receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor antagonist activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
aldosterone secretion IEA
Inferred from Electronic Annotation
more info
 
angiotensin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling TAS
Traceable Author Statement
more info
PubMed 
brain development NAS
Non-traceable Author Statement
more info
PubMed 
brain renin-angiotensin system IEA
Inferred from Electronic Annotation
more info
 
cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular sodium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cerebellar cortex development IEA
Inferred from Electronic Annotation
more info
 
dopamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
exploration behavior IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of blood vessel endothelial cell migration NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of icosanoid secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neurotrophin TRK receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of norepinephrine secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
nitric oxide mediated signal transduction IC
Inferred by Curator
more info
PubMed 
nitric oxide mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
positive regulation of blood vessel diameter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of metanephric glomerulus development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric oxide biosynthetic process IC
Inferred by Curator
more info
PubMed 
positive regulation of nitric-oxide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
regulation of metanephros size IEA
Inferred from Electronic Annotation
more info
 
regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure by circulatory renin-angiotensin ISS
Inferred from Sequence or Structural Similarity
more info
 
renin-angiotensin regulation of aldosterone production IEA
Inferred from Electronic Annotation
more info
 
vasodilation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
type-2 angiotensin II receptor
Names
angiotensin II type-2 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016326.1 RefSeqGene

    Range
    5040..9270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000686.5NP_000677.2  type-2 angiotensin II receptor

    See identical proteins and their annotated locations for NP_000677.2

    Status: REVIEWED

    Source sequence(s)
    AI911273, AL732602, BC095504, CR738498, DA538369, U16957
    Consensus CDS
    CCDS14569.1
    UniProtKB/Swiss-Prot
    P50052
    Related
    ENSP00000360973.4, ENST00000371906.5
    Conserved Domains (1) summary
    pfam00001
    Location:62318
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    116170744..116174974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537533.1XP_011535835.1  type-2 angiotensin II receptor isoform X1

    See identical proteins and their annotated locations for XP_011535835.1

    UniProtKB/Swiss-Prot
    P50052
    Conserved Domains (1) summary
    pfam00001
    Location:62318
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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