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AGTR2 angiotensin II receptor type 2 [ Homo sapiens (human) ]

Gene ID: 186, updated on 5-Jan-2022

Summary

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Official Symbol
AGTR2provided by HGNC
Official Full Name
angiotensin II receptor type 2provided by HGNC
Primary source
HGNC:HGNC:338
See related
Ensembl:ENSG00000180772 MIM:300034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AT2; ATGR2; MRX88
Summary
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients. [provided by RefSeq, Jul 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression
Biased expression in lung (RPKM 5.8), endometrium (RPKM 4.4) and 2 other tissues See more
Orthologs
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Genomic context

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See AGTR2 in Genome Data Viewer
Location:
Xq23
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (116170744..116174974)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (115301997..115306227)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1 member B1 pseudogene 8 Neighboring gene apoptosis inhibitor 5 pseudogene 1 Neighboring gene RNA, U6 small nuclear 154, pseudogene Neighboring gene solute carrier family 6 member 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Variants in AGTR2 gene in Maya people with COVID-19. Totomoch-Serra A, et al. Gene, 2021 Aug 30. PMID 34175388, Free PMC Article
  2. Preoperative angiotensin II type 2 receptor is a predictor for developing chronic post-surgical pain after total knee arthroplasty surgery. Chen F, et al. Life Sci, 2021 Aug 1. PMID 34043993
  3. AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells. Cui C, et al. IEEE/ACM Trans Comput Biol Bioinform, 2021 Jul-Aug. PMID 32750889
  4. A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm. Garvin MR, et al. Elife, 2020 Jul 7. PMID 32633718, Free PMC Article
  5. The pivotal link between ACE2 deficiency and SARS-CoV-2 infection. Verdecchia P, et al. Eur J Intern Med, 2020 Jun. PMID 32336612, Free PMC Article

See all (241) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Colon adenocarcinoma-derived cells possessing stem cell function can be modulated using renin-angiotensin system inhibitors.
    Title: Colon adenocarcinoma-derived cells possessing stem cell function can be modulated using renin-angiotensin system inhibitors.
  2. GABA is a mediator of brain AT1 and AT2 receptor-mediated blood pressure responses.
    Title: GABA is a mediator of brain AT<sub>1</sub> and AT<sub>2</sub> receptor-mediated blood pressure responses.
  3. AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells.
    Title: AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells.
  4. Variants in AGTR2 gene in Maya people with COVID-19.
    Title: Variants in AGTR2 gene in Maya people with COVID-19.
  5. Preoperative angiotensin II type 2 receptor is a predictor for developing chronic post-surgical pain after total knee arthroplasty surgery.
    Title: Preoperative angiotensin II type 2 receptor is a predictor for developing chronic post-surgical pain after total knee arthroplasty surgery.
  6. The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.
    Title: The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.
  7. The discovery of a new antibody for BRIL-fused GPCR structure determination.
    Title: The discovery of a new antibody for BRIL-fused GPCR structure determination.
  8. Brain Angiotensin Type-1 and Type-2 Receptors in Physiological and Hypertensive Conditions: Focus on Neuroinflammation.
    Title: Brain Angiotensin Type-1 and Type-2 Receptors in Physiological and Hypertensive Conditions: Focus on Neuroinflammation.
  9. Seminal levels of angiotensin II and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients: Relation to fertility status.
    Title: Seminal levels of angiotensin II and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients: Relation to fertility status.
  10. findings suggest that prior activation of AT2R is prophylactic in preventing LPS-induced renal immune cell infiltration and dysfunction, possibly via IL-10 pathway.
    Title: Prevention of lipopolysaccharide-induced CD11b<sup>+</sup> immune cell infiltration in the kidney: role of AT<sub>2</sub> receptors.
Submit: New GeneRIF Correction See all GeneRIFs (161)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-05-10)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-05-10)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables angiotensin type II receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables angiotensin type II receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor antagonist activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IC
Inferred by Curator
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in angiotensin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
  
involved_in blood vessel remodeling TAS
Traceable Author Statement
more info
 PubMed 
involved_in brain development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in brain renin-angiotensin system IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in exploration behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of blood vessel endothelial cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell growth TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of neurotrophin TRK receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in nitric oxide mediated signal transduction IC
Inferred by Curator
more info
 PubMed 
involved_in nitric oxide mediated signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of metanephric glomerulus development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of nitric oxide biosynthetic process IC
Inferred by Curator
more info
 PubMed 
involved_in positive regulation of nitric-oxide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of blood pressure TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of metanephros size IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of systemic arterial blood pressure by circulatory renin-angiotensin ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vasodilation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in integral component of plasma membrane IC
Inferred by Curator
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
type-2 angiotensin II receptor
Names
angiotensin II type-2 receptor

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016326.1 RefSeqGene

    Range
    5040..9270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000686.5 → NP_000677.2  type-2 angiotensin II receptor isoform 1

    See identical proteins and their annotated locations for NP_000677.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI911273, AL732602, BC095504, CR738498, DA538369, U16957
    Consensus CDS
    CCDS14569.1
    UniProtKB/Swiss-Prot
    P50052
    Related
    ENSP00000360973.4, ENST00000371906.5
    Conserved Domains (1) summary
    cd15191
    Location:45 → 329
    7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001385624.1 → NP_001372553.1  type-2 angiotensin II receptor isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the non-coding region compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL732602
    Related
    ENSP00000505750.1, ENST00000681852.1
    Conserved Domains (1) summary
    cd15191
    Location:45 → 329
    7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    116170744..116174974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50052.1 GenPept UniProtKB/Swiss-Prot:P50052

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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