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Pdgfrb platelet derived growth factor receptor, beta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 18596, updated on 28-Nov-2021

Summary

Official Symbol
Pdgfrbprovided by MGI
Official Full Name
platelet derived growth factor receptor, beta polypeptideprovided by MGI
Primary source
MGI:MGI:97531
See related
Ensembl:ENSMUSG00000024620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdgfr; CD140b; PDGFR-1; AI528809
Expression
Broad expression in lung adult (RPKM 46.3), subcutaneous fat pad adult (RPKM 35.2) and 24 other tissues See more
Orthologs
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Genomic context

See Pdgfrb in Genome Data Viewer
Location:
18 E1; 18 34.41 cM
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61178194..61218139)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61045127..61085067)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (61204804..61244721)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 Neighboring gene caudal type homeobox 1 Neighboring gene predicted gene, 52351 Neighboring gene Csf1r promoter/intronic regulatory region Neighboring gene colony stimulating factor 1 receptor Neighboring gene microRNA 6983

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor beta-receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables platelet-derived growth factor beta-receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables platelet-derived growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor binding TAS
Traceable Author Statement
more info
PubMed 
enables platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables platelet-derived growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adrenal gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in aorta morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within blood vessel development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cardiac myofibril assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac vascular smooth muscle cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration involved in coronary angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration involved in vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic organ development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lung growth ISO
Inferred from Sequence Orthology
more info
 
involved_in metanephric glomerular capillary formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in metanephric glomerular mesangial cell proliferation involved in metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metanephric glomerular mesangium development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in metanephric mesenchymal cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nitrogen compound metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatic stellate cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of smooth muscle cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to ceramide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retina vasculature development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in retina vasculature development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ruffle assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle cell chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in intrinsic component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
platelet-derived growth factor receptor beta
Names
CD140 antigen-like family member B
PDGF beta chain
PDGF-R-beta
PDGFR-beta
beta platelet-derived growth factor receptor
beta-type platelet-derived growth factor receptor
platelet-derived growth factor receptor 1
platelet-derived growth factor receptor beta variant 1
NP_001139740.1
NP_032835.2
XP_011245158.1
XP_030106221.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146268.1NP_001139740.1  platelet-derived growth factor receptor beta isoform 1 precursor

    See identical proteins and their annotated locations for NP_001139740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK143247, BB291987, BY753644, X04367
    Consensus CDS
    CCDS50300.1
    UniProtKB/Swiss-Prot
    P05622
    UniProtKB/TrEMBL
    E9QPE2
    Related
    ENSMUSP00000025522.5, ENSMUST00000025522.11
    Conserved Domains (6) summary
    smart00409
    Location:334412
    IG; Immunoglobulin
    smart00410
    Location:221309
    IG_like; Immunoglobulin like
    pfam00047
    Location:36113
    ig; Immunoglobulin domain
    pfam07714
    Location:600953
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:313414
    Ig; Immunoglobulin domain
    cl21453
    Location:562953
    PKc_like; Protein Kinases, catalytic domain
  2. NM_008809.2NP_032835.2  platelet-derived growth factor receptor beta isoform 2 precursor

    See identical proteins and their annotated locations for NP_032835.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame splice site, compared to variant 1, that results in an isoform (2) that is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK143247, BB291987, BY753644, X04367
    UniProtKB/Swiss-Prot
    P05622
    Conserved Domains (3) summary
    pfam00047
    Location:36113
    ig; Immunoglobulin domain
    cl11960
    Location:313414
    Ig; Immunoglobulin domain
    cl21453
    Location:561952
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61178194..61218139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250361.2XP_030106221.1  platelet-derived growth factor receptor beta isoform X2

    Conserved Domains (2) summary
    pfam00047
    Location:36113
    ig; Immunoglobulin domain
    cl11960
    Location:313414
    Ig; Immunoglobulin domain
  2. XM_011246856.3XP_011245158.1  platelet-derived growth factor receptor beta isoform X1

    Conserved Domains (2) summary
    pfam00047
    Location:36113
    ig; Immunoglobulin domain
    cl11960
    Location:313414
    Ig; Immunoglobulin domain
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