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Pdgfra platelet derived growth factor receptor, alpha polypeptide [ Mus musculus (house mouse) ]

Gene ID: 18595, updated on 13-Feb-2024

Summary

Official Symbol
Pdgfraprovided by MGI
Official Full Name
platelet derived growth factor receptor, alpha polypeptideprovided by MGI
Primary source
MGI:MGI:97530
See related
Ensembl:ENSMUSG00000029231 AllianceGenome:MGI:97530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD140a; Pdgfr-2
Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]
Expression
Broad expression in limb E14.5 (RPKM 29.6), lung adult (RPKM 20.2) and 19 other tissues See more
Orthologs
NEW
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Genomic context

See Pdgfra in Genome Data Viewer
Location:
5 C3.3; 5 39.55 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (75311988..75358867)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (75151322..75198206)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19583 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, pseudogene Neighboring gene olfactory receptor 1401, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E8936 Neighboring gene STARR-seq mESC enhancer starr_13421 Neighboring gene microRNA 7025 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 pseudogene Neighboring gene sterol O-acyltransferase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor alpha-receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables platelet-derived growth factor alpha-receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables platelet-derived growth factor alpha-receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables platelet-derived growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables platelet-derived growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor binding TAS
Traceable Author Statement
more info
PubMed 
enables platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Leydig cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adrenal gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within anatomical structure morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac myofibril assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic cranial skeleton morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within estrogen metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within face morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within female gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lung growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within luteinization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within luteinization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male genitalia development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric glomerular capillary formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet-derived growth factor receptor-alpha signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in platelet-derived growth factor receptor-alpha signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of branching involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mesenchymal stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in retina vasculature development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within white fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
platelet-derived growth factor receptor alpha
Names
Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)
CD140 antigen-like family member A
PDGF alpha chain
PDGF-R-alpha
PDGFR-alpha
alpha-type platelet-derived growth factor receptor
NP_001076785.1
NP_001334647.1
NP_001334648.1
NP_035188.2
XP_006504324.1
XP_006504325.1
XP_006504326.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083316.2NP_001076785.1  platelet-derived growth factor receptor alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_001076785.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK147267, BC053036, BY628767, CD354225, CK627326
    Consensus CDS
    CCDS19351.1
    UniProtKB/Swiss-Prot
    P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3
    Related
    ENSMUSP00000127173.2, ENSMUST00000168162.5
    Conserved Domains (5) summary
    cd04972
    Location:416497
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05859
    Location:313413
    Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
    cd05861
    Location:228311
    Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
    cd05105
    Location:555956
    PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
    pfam13927
    Location:28100
    Ig_3; Immunoglobulin domain
  2. NM_001347718.1NP_001334647.1  platelet-derived growth factor receptor alpha isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and its 3' terminal exon extends past a splice site that is used in variant 1, which results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2, also known as 'In-PDGFRalpha') is shorter and has a distinct C-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC120348, AK081664, AK147267
    Consensus CDS
    CCDS89929.1
    UniProtKB/Swiss-Prot
    P26618
    Related
    ENSMUSP00000143906.2, ENSMUST00000202681.4
  3. NM_001347719.1NP_001334648.1  platelet-derived growth factor receptor alpha isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and its 3' terminal exon extends past a splice site that is used in variant 1, which results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2, also known as 'In-PDGFRalpha') is shorter and has a distinct C-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC120348, AK081664, AK147267
    Consensus CDS
    CCDS89929.1
    UniProtKB/Swiss-Prot
    P26618
    Related
    ENSMUSP00000143891.2, ENSMUST00000201711.4
  4. NM_011058.3NP_035188.2  platelet-derived growth factor receptor alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_035188.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC120348, AK147267, BY628767, CK627326
    Consensus CDS
    CCDS19351.1
    UniProtKB/Swiss-Prot
    P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3
    Related
    ENSMUSP00000000476.9, ENSMUST00000000476.15
    Conserved Domains (5) summary
    cd04972
    Location:416497
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05859
    Location:313413
    Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
    cd05861
    Location:228311
    Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
    cd05105
    Location:555956
    PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
    pfam13927
    Location:28100
    Ig_3; Immunoglobulin domain

RNA

  1. NR_144636.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) includes a 3' terminal exon that extends past a splice site that is used in variant 1. This variant is represented as non-coding because it lacks a stop codon, rendering the transcript a candidate for non-stop decay.
    Source sequence(s)
    AC120348, AK139094, AK147267
    Related
    ENSMUST00000202186.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    75311988..75358867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504263.5XP_006504326.1  platelet-derived growth factor receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006504326.1

    UniProtKB/Swiss-Prot
    P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3
    Conserved Domains (5) summary
    cd04972
    Location:416497
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05859
    Location:313413
    Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
    cd05861
    Location:228311
    Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
    cd05105
    Location:555956
    PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
    pfam13927
    Location:28100
    Ig_3; Immunoglobulin domain
  2. XM_006504261.5XP_006504324.1  platelet-derived growth factor receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006504324.1

    UniProtKB/Swiss-Prot
    P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3
    Conserved Domains (5) summary
    cd04972
    Location:416497
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05859
    Location:313413
    Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
    cd05861
    Location:228311
    Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
    cd05105
    Location:555956
    PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
    pfam13927
    Location:28100
    Ig_3; Immunoglobulin domain
  3. XM_006504262.5XP_006504325.1  platelet-derived growth factor receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006504325.1

    UniProtKB/Swiss-Prot
    P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3
    Conserved Domains (5) summary
    cd04972
    Location:416497
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05859
    Location:313413
    Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
    cd05861
    Location:228311
    Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
    cd05105
    Location:555956
    PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
    pfam13927
    Location:28100
    Ig_3; Immunoglobulin domain