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Pdgfb platelet derived growth factor, B polypeptide [ Mus musculus (house mouse) ]

Gene ID: 18591, updated on 22-Jan-2023

Summary

Official Symbol
Pdgfbprovided by MGI
Official Full Name
platelet derived growth factor, B polypeptideprovided by MGI
Primary source
MGI:MGI:97528
See related
Ensembl:ENSMUSG00000000489 AllianceGenome:MGI:97528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sis; c-sis; PDGF-2; PDGF-B
Summary
Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including metanephric glomerular mesangium development; paracrine signaling; and positive regulation of glomerular filtration. Acts upstream of or within several processes, including animal organ development; nervous system development; and regulation of cell migration. Predicted to be located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 24.0), adrenal adult (RPKM 10.1) and 20 other tissues See more
Orthologs
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Genomic context

See Pdgfb in Genome Data Viewer
Location:
15 E1; 15 37.85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79880066..79899178, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79995865..80024614, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene chromobox 7 Neighboring gene VISTA enhancer mm570 Neighboring gene predicted gene, 53903 Neighboring gene microRNA 7213 Neighboring gene predicted gene, 41361 Neighboring gene predicted gene, 53904 Neighboring gene predicted gene, 41362

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables superoxide-generating NADPH oxidase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac vascular smooth muscle cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell projection assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mycophenolic acid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to platelet-derived growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within eye photoreceptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of fibroblast migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within glial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-18-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in metanephric glomerular endothelium development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in metanephric glomerular mesangial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric glomerular mesangial cell proliferation involved in metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in paracrine signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of phosphatidylinositol 3-kinase signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in platelet-derived growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet-derived growth factor receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of fibroblast migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glomerular filtration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatic stellate cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatic stellate cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of metanephric mesenchymal cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mitotic cell cycle, embryonic IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell dedifferentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction TAS
Traceable Author Statement
more info
PubMed 
involved_in protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retina vasculature development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within substrate-dependent cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of vascular associated smooth muscle cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of vascular associated smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vasoconstriction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
part_of platelet-derived growth factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
platelet-derived growth factor subunit B
Names
PDGF subunit B
platelet-derived growth factor B chain
platelet-derived growth factor beta polypeptide
proto-oncogene c-Sis

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411619.1NP_001398548.1  platelet-derived growth factor subunit B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113595
  2. NM_001411620.1NP_001398549.1  platelet-derived growth factor subunit B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113595
  3. NM_011057.5NP_035187.2  platelet-derived growth factor subunit B isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_035187.2

    Status: VALIDATED

    Source sequence(s)
    AC113595
    Consensus CDS
    CCDS27656.1
    UniProtKB/Swiss-Prot
    P31240
    UniProtKB/TrEMBL
    A0A0R4IZW4, A0A8C6ID92
    Related
    ENSMUSP00000000500.7, ENSMUST00000000500.8
    Conserved Domains (2) summary
    pfam00341
    Location:97180
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:2193
    PDGF_N; Platelet-derived growth factor, N terminal region

RNA

  1. NR_177435.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113595
  2. NR_177436.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113595
  3. NR_177437.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113595

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79880066..79899178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159241.1XP_036015134.1  platelet-derived growth factor subunit B isoform X2

    Conserved Domains (1) summary
    pfam00341
    Location:34117
    PDGF; PDGF/VEGF domain
  2. XM_036159240.1XP_036015133.1  platelet-derived growth factor subunit B isoform X1

    Conserved Domains (2) summary
    pfam00341
    Location:66149
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:162
    PDGF_N; Platelet-derived growth factor, N terminal region
  3. XM_006520592.5XP_006520655.1  platelet-derived growth factor subunit B isoform X2

    Conserved Domains (1) summary
    pfam00341
    Location:34117
    PDGF; PDGF/VEGF domain
  4. XM_030248410.2XP_030104270.1  platelet-derived growth factor subunit B isoform X1

    Related
    ENSMUSP00000155133.2, ENSMUST00000229912.2
    Conserved Domains (2) summary
    pfam00341
    Location:66149
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:162
    PDGF_N; Platelet-derived growth factor, N terminal region
  5. XM_030248411.2XP_030104271.1  platelet-derived growth factor subunit B isoform X2

    Conserved Domains (1) summary
    pfam00341
    Location:34117
    PDGF; PDGF/VEGF domain
  6. XM_030248409.2XP_030104269.1  platelet-derived growth factor subunit B isoform X1

    Conserved Domains (2) summary
    pfam00341
    Location:66149
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:162
    PDGF_N; Platelet-derived growth factor, N terminal region