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Pde6b phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 18587, updated on 8-Apr-2026
Official Symbol
Pde6bprovided by MGI
Official Full Name
phosphodiesterase 6B, cGMP, rod receptor, beta polypeptideprovided by MGI
Primary source
MGI:MGI:97525
See related
Ensembl:ENSMUSG00000029491 AllianceGenome:MGI:97525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
r; rd; rd1; Pdeb; rd-1; rd10
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in entrainment of circadian clock by photoperiod. Acts upstream of or within detection of light stimulus and retina development in camera-type eye. Located in photoreceptor outer segment. Is expressed in esophagus; eye; and male reproductive gland or organ. Used to study congenital stationary night blindness autosomal dominant 2; retinal degeneration; retinitis pigmentosa; and retinitis pigmentosa 40. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 2 and retinitis pigmentosa 40. Orthologous to human PDE6B (phosphodiesterase 6B). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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See Pde6b in Genome Data Viewer
Location:
5 F; 5 53.07 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108536239..108579609)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108388373..108431743)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 271, retrotransposed Neighboring gene predicted gene 10419 Neighboring gene predicted gene, 52851 Neighboring gene predicted gene, 34254 Neighboring gene STARR-positive B cell enhancer ABC_E9648 Neighboring gene ATP synthase membrane subunit e Neighboring gene predicted gene, 34319 Neighboring gene solute carrier family 49 member 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration. Alvarez-López C, et al. Brain Res, 2006 May 4. PMID 16626665
  2. Method to remove photoreceptors from whole mount retina in vitro. Walston ST, et al. J Neurophysiol, 2017 Nov 1. PMID 28855296, Free PMC Article
  3. Tool from ancient pharmacopoeia prevents vision loss. Boatright JH, et al. Mol Vis, 2006 Dec 29. PMID 17213800
  4. Effect of photoreceptor degeneration on RNA splicing and expression of AMPA receptors. Namekata K, et al. Mol Vis, 2006 Dec 13. PMID 17200657
  5. Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study. Gargini C, et al. J Comp Neurol, 2007 Jan 10. PMID 17111372, Free PMC Article

See all (767) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a simple and effective PCR based method for genotyping rd1 (Pde6b) and rd8 (Crb1) in mice.
    Title: Genotyping single point mutations in rd1 and rd8 mice using melting curve analysis of qPCR fragments.
  2. The m[6]A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B.
    Title: The m(6)A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B.
  3. PKM2 can regulate transcriptional activity of PDE6B via its promoter in a mouse retinal degeneration model.
    Title: Pyruvate kinase M2 regulates photoreceptor structure, function, and viability.
  4. Retinal degeneration was slowed down in Cngb1/Pde6b double knock-out mice due to lowering of cGMP content in the retinas, and suggests that it may be caused by mislocalization of active Pde6b.
    Title: The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx.
  5. The retinal degeneration (rd) mutant mouse, which carries a genetic mutation of PDE6b.
    Title: Neurotoxicity of cGMP in the vertebrate retina: from the initial research on rd mutant mice to zebrafish genetic approaches.
  6. These results clearly show that the development of early-onset cataracts requires at least two mutant alleles of Foxe3(rct) and Pde6b(rd1), and another modifier associated with the severity of cataract phenotypes in Foxe3(rct) mice underlies the genetic backgrounds in mice.
    Title: Pde6b(rd1) mutation modifies cataractogenesis in Foxe3(rct) mice.
  7. demonstrated a substantial difference in the speed of retinal degeneration and accompanying loss of visual function between two rd1 lines
    Title: Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 mice.
  8. transient and Pde6-independent Ca(2+) elevations ('flashes') were detected throughout the inner segment and the synapse.
    Title: Loss of Pde6 reduces cell body Ca(2+) transients within photoreceptors.
  9. Polyglutamine expansion AR sequesters PTIP to attenuate DNA repair and increase genomic instability.
    Title: A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability.
  10. There are distinct changes that occur in the morphology of retinal pigment epithelium cells in response to retinal degeneration in rd10 mice.
    Title: Analysis of the RPE sheet in the rd10 retinal degeneration model.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC150321

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to 3',5'-cyclic-GMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within detection of light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cAMP/PKA signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retina development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinal cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in retinal cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
  
is_active_in photoreceptor outer segment membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in photoreceptor outer segment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor outer segment membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of rod photoreceptor phosphodiesterase 6 complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Names
GMP-PDE beta
cGMP-phosphodiesterase beta-subunit
phosphodiesterase, cGMP, rod receptor, beta polypeptide
retinal degeneration 1
NP_032832.2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008806.2 → NP_032832.2  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

    See identical proteins and their annotated locations for NP_032832.2

    Status: VALIDATED

    Source sequence(s)
    AK044364, BE944318, BU505563
    Consensus CDS
    CCDS19510.1
    UniProtKB/Swiss-Prot
    P23440, Q80UF0
    UniProtKB/TrEMBL
    A2VDG2
    Related
    ENSMUSP00000031456.8, ENSMUST00000031456.8
    Conserved Domains (2) summary
    smart00065
    Location:71 → 230
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:556 → 801
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108536239..108579609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23440.3 GenPept UniProtKB/Swiss-Prot:P23440

Gene LinkOut

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