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Pde3b phosphodiesterase 3B, cGMP-inhibited [ Mus musculus (house mouse) ]

Gene ID: 18576, updated on 5-Jan-2022

Summary

Official Symbol
Pde3bprovided by MGI
Official Full Name
phosphodiesterase 3B, cGMP-inhibitedprovided by MGI
Primary source
MGI:MGI:1333863
See related
Ensembl:ENSMUSG00000030671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI847709; 9830102A01Rik
Summary
Enables protein kinase B binding activity. Acts upstream of or within several processes, including cellular response to insulin stimulus; glucose homeostasis; and regulation of insulin secretion. Located in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PDE3B (phosphodiesterase 3B). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in mammary gland adult (RPKM 10.0), adrenal adult (RPKM 8.2) and 27 other tissues See more
Orthologs
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Genomic context

See Pde3b in Genome Data Viewer
Location:
7 F1; 7 59.46 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (114014388..114137173)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114415222..114537938)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (121558768..121681451)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene coatomer protein complex, subunit beta 1 Neighboring gene proteasome subunit alpha 1 Neighboring gene RIKEN cDNA 4933406I18 gene Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1 Neighboring gene calcitonin/calcitonin-related polypeptide, alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase B binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase B binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
part_of guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Names
CGI-PDE B
CGIPDE1
cyclic GMP-inhibited phosphodiesterase B
NP_035185.2
XP_006507501.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011055.2NP_035185.2  cGMP-inhibited 3',5'-cyclic phosphodiesterase B

    Status: VALIDATED

    Source sequence(s)
    AJ132271, AK142889, AV270888, BB627812, BB663310, BU613166, BY745829, CJ058099, CJ299201
    Consensus CDS
    CCDS21760.1
    UniProtKB/Swiss-Prot
    Q61409
    UniProtKB/TrEMBL
    E9QLQ3, Q3UQ25
    Related
    ENSMUSP00000032909.9, ENSMUST00000032909.9
    Conserved Domains (2) summary
    pfam00233
    Location:712986
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam06532
    Location:60241
    DUF1109; Protein of unknown function (DUF1109)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    114014388..114137173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507438.5XP_006507501.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1

    Conserved Domains (2) summary
    pfam00233
    Location:695969
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam10101
    Location:116260
    DUF2339; Predicted membrane protein (DUF2339)

RNA

  1. XR_001785490.3 RNA Sequence

  2. XR_003946416.2 RNA Sequence

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