U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pcsk2 proprotein convertase subtilisin/kexin type 2 [ Mus musculus (house mouse) ]

Gene ID: 18549, updated on 9-May-2024

Summary

Official Symbol
Pcsk2provided by MGI
Official Full Name
proprotein convertase subtilisin/kexin type 2provided by MGI
Primary source
MGI:MGI:97512
See related
Ensembl:ENSMUSG00000027419 AllianceGenome:MGI:97512
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PC2; Nec2; SPC2; Nec-2; Phpp-2; 6330411F23Rik
Summary
Enables serine-type endopeptidase activity. Involved in enkephalin processing and protein autoprocessing. Acts upstream of or within nervous system development and proteolysis. Located in extracellular space. Is expressed in brain; endocrine gland; future brain; and gut. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 46.1), frontal lobe adult (RPKM 33.5) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pcsk2 in Genome Data Viewer
Location:
2 G1; 2 70.89 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (143388053..143658204)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (143546133..143816284)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33599 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene proprotein convertase subtilisin/kexin type 2, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_05885 Neighboring gene STARR-seq mESC enhancer starr_05886 Neighboring gene STARR-seq mESC enhancer starr_05887 Neighboring gene STARR-seq mESC enhancer starr_05889 Neighboring gene proprotein convertase subtilisin/kexin type 2, opposite strand 2 Neighboring gene predicted gene, 52527 Neighboring gene STARR-positive B cell enhancer ABC_E4506 Neighboring gene beaded filament structural protein 1, in lens-CP94 Neighboring gene ribosomal protein S13, pseudogene 6 Neighboring gene predicted gene, 33648

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity TAS
Traceable Author Statement
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in enkephalin processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin processing ISO
Inferred from Sequence Orthology
more info
 
involved_in islet amyloid polypeptide processing ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in peptide hormone processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptide hormone processing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptide hormone processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptide hormone processing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoprocessing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuroendocrine convertase 2
Names
KEX2-like endoprotease 2
NEC 2
prohormone convertase 2
proprotein convertase 2
NP_032818.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008792.4NP_032818.1  neuroendocrine convertase 2 precursor

    See identical proteins and their annotated locations for NP_032818.1

    Status: VALIDATED

    Source sequence(s)
    AK158598, AL807801, BC057348
    Consensus CDS
    CCDS16810.1
    UniProtKB/Swiss-Prot
    P21661, Q80WU1
    UniProtKB/TrEMBL
    Q3TYM6, Q547J8
    Related
    ENSMUSP00000028905.10, ENSMUST00000028905.10
    Conserved Domains (4) summary
    cd04059
    Location:121417
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:157434
    Peptidase_S8; Subtilase family
    pfam01483
    Location:503590
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:32108
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    143388053..143658204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)