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Pcolce procollagen C-endopeptidase enhancer protein [ Mus musculus (house mouse) ]

Gene ID: 18542, updated on 12-May-2024


Official Symbol
Pcolceprovided by MGI
Official Full Name
procollagen C-endopeptidase enhancer proteinprovided by MGI
Primary source
See related
Ensembl:ENSMUSG00000029718 AllianceGenome:MGI:105099
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P14; Astt2; Astt-2; PCPE-1
Predicted to enable collagen binding activity; heparin binding activity; and peptidase activator activity. Acts upstream of or within cellular response to leukemia inhibitory factor and proteolysis. Located in extracellular space. Is expressed in several structures, including adrenal gland; branchial arch; embryo endoderm; lower jaw; and umbilical blood vessel. Orthologous to human PCOLCE (procollagen C-endopeptidase enhancer). [provided by Alliance of Genome Resources, Apr 2022]
Biased expression in adrenal adult (RPKM 519.4), ovary adult (RPKM 131.5) and 9 other tissues See more
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Genomic context

See Pcolce in Genome Data Viewer
5 G2; 5 76.59 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137603369..137609666, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137605105..137611522, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2180 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138038199-138038386 Neighboring gene motile sperm domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138041904-138042125 Neighboring gene STARR-positive B cell enhancer ABC_E281 Neighboring gene predicted gene 7285 Neighboring gene predicted gene, 36266 Neighboring gene F-box protein 24 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding IBA
Inferred from Biological aspect of Ancestor
more info
enables collagen binding ISO
Inferred from Sequence Orthology
more info
enables heparin binding ISO
Inferred from Sequence Orthology
more info
enables peptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
enables peptidase activator activity ISO
Inferred from Sequence Orthology
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
located_in extracellular space HDA PubMed 

General protein information

Preferred Names
procollagen C-endopeptidase enhancer 1
astroglial cell transcript 2
procollagen C-proteinase enhancer 1
procollagen C-proteinase enhancer protein
procollagen COOH-terminal proteinase enhancer 1
type 1 procollagen C-proteinase enhancer protein
type I procollagen COOH-terminal proteinase enhancer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008788.2NP_032814.2  procollagen C-endopeptidase enhancer 1 precursor

    See identical proteins and their annotated locations for NP_032814.2

    Status: VALIDATED

    Source sequence(s)
    AK144392, CX210896
    Consensus CDS
    O35113, Q61398
    Q3TX39, Q3UIP2
    ENSMUSP00000031731.8, ENSMUST00000031731.14
    Conserved Domains (2) summary
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000071.7 Reference GRCm39 C57BL/6J

    137603369..137609666 complement
    GenBank, FASTA, Sequence Viewer (Graphics)