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Pcolce procollagen C-endopeptidase enhancer protein [ Mus musculus (house mouse) ]

Gene ID: 18542, updated on 22-May-2018

Summary

Official Symbol
Pcolceprovided by MGI
Official Full Name
procollagen C-endopeptidase enhancer proteinprovided by MGI
Primary source
MGI:MGI:105099
See related
Ensembl:ENSMUSG00000029718 Vega:OTTMUSG00000021947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P14; Astt2; Astt-2; PCPE-1
Expression
Biased expression in adrenal adult (RPKM 519.4), ovary adult (RPKM 131.5) and 9 other tissues See more
Orthologs

Genomic context

See Pcolce in Genome Data Viewer
Location:
5 G2; 5 76.59 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (137605105..137611764, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (138046335..138052632, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene motile sperm domain containing 3 Neighboring gene predicted gene 7285 Neighboring gene predicted gene, 36266 Neighboring gene F-box protein 24 Neighboring gene cytochrome b-c1 complex subunit 7-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
collagen binding ISO
Inferred from Sequence Orthology
more info
PubMed 
heparin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
peptidase activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 

General protein information

Preferred Names
procollagen C-endopeptidase enhancer 1
Names
astroglial cell transcript 2
procollagen C-proteinase enhancer 1
procollagen C-proteinase enhancer protein
procollagen COOH-terminal proteinase enhancer 1
type 1 procollagen C-proteinase enhancer protein
type I procollagen COOH-terminal proteinase enhancer

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008788.2NP_032814.2  procollagen C-endopeptidase enhancer 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AK144392, CX210896
    Consensus CDS
    CCDS39334.1
    UniProtKB/Swiss-Prot
    Q61398
    UniProtKB/TrEMBL
    Q3UIP2, Q3UN82
    Related
    ENSMUSP00000031731.7, OTTMUSP00000024635, ENSMUST00000031731.13, OTTMUST00000052096
    Conserved Domains (2) summary
    cd00041
    Location:36146
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd03576
    Location:334460
    NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    137605105..137611764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504558.3XP_006504621.1  procollagen C-endopeptidase enhancer 1 isoform X1

    UniProtKB/TrEMBL
    D3YUE2
    Related
    ENSMUSP00000057002.6, OTTMUSP00000024636, ENSMUST00000054564.12, OTTMUST00000052097
    Conserved Domains (2) summary
    cd00041
    Location:36146
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd03576
    Location:359485
    NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...
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