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Pcna proliferating cell nuclear antigen [ Mus musculus (house mouse) ]

Gene ID: 18538, updated on 10-Jan-2023

Summary

Official Symbol
Pcnaprovided by MGI
Official Full Name
proliferating cell nuclear antigenprovided by MGI
Primary source
MGI:MGI:97503
See related
Ensembl:ENSMUSG00000027342 AllianceGenome:MGI:97503
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables enzyme binding activity. Involved in mitotic telomere maintenance via semi-conservative replication and replication fork processing. Acts upstream of or within base-excision repair, gap-filling; cellular response to xenobiotic stimulus; and negative regulation of transcription by RNA polymerase II. Located in nuclear lamina and replication fork. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including alimentary system; brain; forelimb; heart; and sensory organ. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 270.8), liver E14 (RPKM 268.7) and 26 other tissues See more
Orthologs
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Genomic context

See Pcna in Genome Data Viewer
Location:
2 F2; 2 64.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132091206..132095100, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132249286..132253180, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14051 Neighboring gene predicted gene, 29720 Neighboring gene transmembrane protein 230 Neighboring gene expressed sequence AV099323 Neighboring gene predicted gene, 46766 Neighboring gene CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA polymerase processivity factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MutLalpha complex binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables dinucleotide insertion or deletion binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables purine-specific mismatch base pair DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within base-excision repair, gap-filling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mismatch repair ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic telomere maintenance via semi-conservative replication IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of deoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in replication fork processing IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to lipid ISO
Inferred from Sequence Orthology
more info
 
involved_in translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translesion synthesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of PCNA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of PCNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of PCNA-p21 complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear lamina IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in replication fork IDA
Inferred from Direct Assay
more info
PubMed 
located_in replication fork ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
proliferating cell nuclear antigen
Names
cyclin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011045.2NP_035175.1  proliferating cell nuclear antigen

    See identical proteins and their annotated locations for NP_035175.1

    Status: PROVISIONAL

    Source sequence(s)
    AL807793
    Consensus CDS
    CCDS16771.1
    UniProtKB/Swiss-Prot
    P17918
    UniProtKB/TrEMBL
    A0A8C6HNE6, Q542J9
    Related
    ENSMUSP00000028817.7, ENSMUST00000028817.7
    Conserved Domains (2) summary
    cd00577
    Location:4256
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    TIGR00590
    Location:1259
    pcna; proliferating cell nuclear antigen (pcna)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    132091206..132095100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)