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erh-2 Enhancer of rudimentary homolog 2 [ Caenorhabditis elegans ]

Gene ID: 185323, updated on 4-Feb-2026
Official Symbol
erh-2
Official Full Name
Enhancer of rudimentary homolog 2
Primary source
WormBase:WBGene00009444
Locus tag
CELE_F35G12.11
See related
AllianceGenome:WB:WBGene00009444
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in piRNA processing; positive regulation of cell division; and positive regulation of chromosome segregation. Located in nucleus and perinuclear region of cytoplasm. Is expressed in germ line. Orthologous to human ERH (ERH mRNA splicing and mitosis factor). [provided by Alliance of Genome Resources, Jul 2025]
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Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (4593231..4593827)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene GUN4 domain-containing protein;Ras-associating domain-containing protein;SPK domain-containing protein Neighboring gene Divalent-cation tolerance protein CutA Neighboring gene Structural maintenance of chromosomes protein 4 Neighboring gene Anaphase-promoting complex subunit 11 Neighboring gene ATP synthase F(0) complex subunit B1, mitochondrial

Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Molecular basis for PICS-mediated piRNA biogenesis and cell division. Wang X, et al. Nat Commun, 2021 Sep 22. PMID 34552083, Free PMC Article
  2. Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans. Perez-Borrajero C, et al. Genes Dev, 2021 Sep 1. PMID 34413138, Free PMC Article
  3. Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation. Zeng C, et al. Cell Rep, 2019 Jun 18. PMID 31216475
  4. PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability. Cordeiro Rodrigues RJ, et al. Genes Dev, 2019 Jul 1. PMID 31147388, Free PMC Article
  5. Yolk-deprived Caenorhabditis elegans secure brood size at the expense of competitive fitness. Geens E, et al. Life Sci Alliance, 2023 Jun. PMID 37059473, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 21U-RNA metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in piRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Enhancer of rudimentary homolog 2
NP_497936.2
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4593231..4593827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065535.8 → NP_497936.2  Enhancer of rudimentary homolog 2

    See identical proteins and their annotated locations for NP_497936.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20057
    Conserved Domains (1) summary
    pfam01133
    Location:5 → 100
    ER; Enhancer of rudimentary
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20057.2

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