Format

Send to:

Choose Destination

Pcdh8 protocadherin 8 [ Mus musculus (house mouse) ]

Gene ID: 18530, updated on 12-Aug-2019

Summary

Official Symbol
Pcdh8provided by MGI
Official Full Name
protocadherin 8provided by MGI
Primary source
MGI:MGI:1306800
See related
Ensembl:ENSMUSG00000036422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Papc; 1700080P15Rik
Summary
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported. [provided by RefSeq, Sep 2009]
Expression
Biased expression in whole brain E14.5 (RPKM 19.8), CNS E18 (RPKM 18.6) and 7 other tissues See more
Orthologs

Genomic context

See Pcdh8 in Genome Data Viewer
Location:
14 D3; 14 42.76 cM
Exon count:
3
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79766772..79771312, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (80166582..80171119, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115485928 Neighboring gene microRNA 759 Neighboring gene predicted gene 9748 Neighboring gene predicted gene 10845 Neighboring gene predicted gene 6999 Neighboring gene ubiquitin specific peptidase 15 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
 
somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
integral component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protocadherin-8
Names
arcadlin
paraxial protocadherin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042726.3NP_001036191.1  protocadherin-8 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a protein (isoform 2) with a shorter cytoplasmic domain, compared to isoform 1.
    Source sequence(s)
    AC151973, AK048638, AK140407
    Consensus CDS
    CCDS79349.1
    UniProtKB/Swiss-Prot
    Q7TSK3
    Related
    ENSMUSP00000141417.1, ENSMUST00000195355.1
    Conserved Domains (2) summary
    cd11304
    Location:501605
    Cadherin_repeat; Cadherin tandem repeat domain
    cl09101
    Location:31109
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
  2. NM_021543.4NP_067518.2  protocadherin-8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067518.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC151973, BB597984, BC053008
    Consensus CDS
    CCDS27303.1
    UniProtKB/Swiss-Prot
    Q7TSK3
    Related
    ENSMUSP00000045333.5, ENSMUST00000039568.10
    Conserved Domains (2) summary
    cd11304
    Location:501605
    Cadherin_repeat; Cadherin tandem repeat domain
    cl09101
    Location:31109
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p6 C57BL/6J

    Range
    79766772..79771312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center