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Igbp1 immunoglobulin (CD79A) binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 18518, updated on 26-Sep-2022

Summary

Official Symbol
Igbp1provided by MGI
Official Full Name
immunoglobulin (CD79A) binding protein 1provided by MGI
Primary source
MGI:MGI:1346500
See related
Ensembl:ENSMUSG00000031221 AllianceGenome:MGI:1346500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p52; Pc52; Tap42
Summary
Enables mitogen-activated protein kinase kinase binding activity and protein domain specific binding activity. Involved in negative regulation of protein dephosphorylation; positive regulation of dephosphorylation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of apoptotic signaling pathway. Located in cytoplasm and microtubule. Is expressed in bladder; female associated reproductive structure; ovary; ureter; and urethra of female. Human ortholog(s) of this gene implicated in corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome. Orthologous to human IGBP1 (immunoglobulin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 27.3), placenta adult (RPKM 25.0) and 27 other tissues See more
Orthologs
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Genomic context

See Igbp1 in Genome Data Viewer
Location:
X; X C3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (99537897..99559731)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (100494291..100516125)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ectodysplasin-A Neighboring gene microRNA 676 Neighboring gene acyl-CoA wax alcohol acyltransferase 2 Neighboring gene OTU domain containing 6A Neighboring gene diacylglycerol O-acyltransferase 2-like 6 Neighboring gene acyl-CoA wax alcohol acyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mitogen-activated protein kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase 2A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
immunoglobulin-binding protein 1
Names
CD79a-binding protein 1
alpha 4
alpha4 phosphoprotein
lymphocyte signal transduction molecule alpha 4
phosphoprotein, component, 52 kDa
protein phosphatase 2/4/6 regulatory subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008784.3NP_032810.4  immunoglobulin-binding protein 1

    See identical proteins and their annotated locations for NP_032810.4

    Status: VALIDATED

    Source sequence(s)
    AK017166, BC056186, CX203560, DV654442
    Consensus CDS
    CCDS30302.1
    UniProtKB/Swiss-Prot
    Q61249
    Related
    ENSMUSP00000033570.6, ENSMUST00000033570.6
    Conserved Domains (1) summary
    pfam04177
    Location:17329
    TAP42; TAP42-like family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    99537897..99559731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)