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Pax8 paired box 8 [ Mus musculus (house mouse) ]

Gene ID: 18510, updated on 12-Aug-2018
Official Symbol
Pax8provided by MGI
Official Full Name
paired box 8provided by MGI
Primary source
MGI:MGI:97492
See related
Ensembl:ENSMUSG00000026976 Vega:OTTMUSG00000011957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pax-8
Summary
This gene encodes a member of a family of transcription factors that contain a characteristic N-terminal paired DNA-binding domain. The encoded protein is important for proper differentiation of the thyroid and the kidney. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Mar 2013]
Expression
Biased expression in genital fat pad adult (RPKM 36.6), kidney adult (RPKM 27.4) and 5 other tissues See more
Orthologs
See Pax8 in Genome Data Viewer
Location:
2 A3; 2 16.43 cM
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (24420551..24480095, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (24276080..24331086, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor antagonist Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene predicted gene 13415 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene predicted gene, 39769

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
S-shaped body morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to gonadotropin stimulus ISO
Inferred from Sequence Orthology
more info
 
central nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
kidney epithelium development IEP
Inferred from Expression Pattern
more info
PubMed 
mesonephric tubule development IEP
Inferred from Expression Pattern
more info
PubMed 
mesonephros development IEP
Inferred from Expression Pattern
more info
PubMed 
mesonephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric distal convoluted tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric nephron tubule formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephros development IEP
Inferred from Expression Pattern
more info
PubMed 
metanephros development IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process involved in metanephric collecting duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process involved in metanephric nephron tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mesenchymal cell apoptotic process involved in metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of metanephric DCT cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of thyroid hormone generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
pronephric field specification IEP
Inferred from Expression Pattern
more info
PubMed 
pronephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of metanephric nephron tubule epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of thyroid-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
thyroid gland development IEP
Inferred from Expression Pattern
more info
PubMed 
thyroid gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
thyroid gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid gland development ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
urogenital system development IGI
Inferred from Genetic Interaction
more info
PubMed 
ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
paired box protein Pax-8
Names
paired box gene 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011040.4NP_035170.1  paired box protein Pax-8

    See identical proteins and their annotated locations for NP_035170.1

    Status: REVIEWED

    Source sequence(s)
    AK050717, AL732528, BY442465
    Consensus CDS
    CCDS15738.1
    UniProtKB/Swiss-Prot
    Q00288
    Related
    ENSMUSP00000028355.4, OTTMUSP00000012886, ENSMUST00000028355.10, OTTMUST00000028458
    Conserved Domains (2) summary
    smart00351
    Location:9133
    PAX; Paired Box domain
    pfam12403
    Location:344455
    Pax2_C; Paired-box protein 2 C terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    24420551..24480095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497779.3XP_006497842.1  paired box protein Pax-8 isoform X1

    See identical proteins and their annotated locations for XP_006497842.1

    Conserved Domains (2) summary
    smart00351
    Location:9134
    PAX; Paired Box domain
    pfam12403
    Location:345456
    Pax2_C; Paired-box protein 2 C terminal
  2. XM_006497781.1XP_006497844.1  paired box protein Pax-8 isoform X3

    Related
    ENSMUSP00000134343.3, OTTMUSP00000054435, ENSMUST00000153601.7, OTTMUST00000028462
    Conserved Domains (2) summary
    smart00351
    Location:9133
    PAX; Paired Box domain
    pfam12403
    Location:281386
    Pax2_C; Paired-box protein 2 C terminal
  3. XM_006497780.2XP_006497843.1  paired box protein Pax-8 isoform X2

    Conserved Domains (2) summary
    smart00351
    Location:9134
    PAX; Paired Box domain
    pfam12403
    Location:282387
    Pax2_C; Paired-box protein 2 C terminal
  4. XM_006497778.3XP_006497841.1  paired box protein Pax-8 isoform X1

    See identical proteins and their annotated locations for XP_006497841.1

    Related
    ENSMUSP00000133316.2, OTTMUSP00000012888, ENSMUST00000136228.9, OTTMUST00000028464
    Conserved Domains (2) summary
    smart00351
    Location:9134
    PAX; Paired Box domain
    pfam12403
    Location:345456
    Pax2_C; Paired-box protein 2 C terminal
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