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Pax8 paired box 8 [ Mus musculus (house mouse) ]

Gene ID: 18510, updated on 8-Feb-2024

Summary

Official Symbol
Pax8provided by MGI
Official Full Name
paired box 8provided by MGI
Primary source
MGI:MGI:97492
See related
Ensembl:ENSMUSG00000026976 AllianceGenome:MGI:97492
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pax-8
Summary
This gene encodes a member of a family of transcription factors that contain a characteristic N-terminal paired DNA-binding domain. The encoded protein is important for proper differentiation of the thyroid and the kidney. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Mar 2013]
Expression
Biased expression in genital fat pad adult (RPKM 36.6), kidney adult (RPKM 27.4) and 5 other tissues See more
Orthologs
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Genomic context

See Pax8 in Genome Data Viewer
Location:
2 A3; 2 16.43 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24310563..24365611, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24420551..24475599, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor antagonist Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:24238515-24238668 Neighboring gene STARR-positive B cell enhancer ABC_E11125 Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene predicted gene 13415 Neighboring gene Pax8 promoter region Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene Pax8 CNS1 enhancer Neighboring gene predicted gene, 39769 Neighboring gene Pax8 CNS87 enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in S-shaped body morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to gonadotropin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in kidney epithelium development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mesonephric tubule development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mesonephros development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mesonephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric distal convoluted tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric nephron tubule formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephros development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within metanephros development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process involved in metanephric collecting duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process involved in metanephric nephron tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of metanephric DCT cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of thyroid hormone generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in pronephric field specification IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in pronephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of metanephric nephron tubule epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of thyroid-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in thyroid gland development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within thyroid gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within thyroid gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thyroid gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in urogenital system development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
paired box protein Pax-8
Names
paired box gene 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011040.4NP_035170.1  paired box protein Pax-8

    See identical proteins and their annotated locations for NP_035170.1

    Status: REVIEWED

    Source sequence(s)
    AK050717, AL732528, BY442465
    Consensus CDS
    CCDS15738.1
    UniProtKB/Swiss-Prot
    P97342, Q00288, Q6GU20
    UniProtKB/TrEMBL
    A2AIU7
    Related
    ENSMUSP00000028355.5, ENSMUST00000028355.11
    Conserved Domains (2) summary
    smart00351
    Location:9133
    PAX; Paired Box domain
    pfam12403
    Location:344455
    Pax2_C; Paired-box protein 2 C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    24310563..24365611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)