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AGTR1 angiotensin II receptor type 1 [ Homo sapiens (human) ]

Gene ID: 185, updated on 3-Dec-2017
Official Symbol
AGTR1provided by HGNC
Official Full Name
angiotensin II receptor type 1provided by HGNC
Primary source
HGNC:HGNC:336
See related
Ensembl:ENSG00000144891 MIM:106165; Vega:OTTHUMG00000159503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B
Summary
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
Expression
Biased expression in placenta (RPKM 58.2), fat (RPKM 27.9) and 9 other tissues See more
Orthologs
Location:
3q24
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (148697871..148743003)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (148415658..148460790)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374150 Neighboring gene ribosomal protein L38 pseudogene 1 Neighboring gene high mobility group box 1 pseudogene 30 Neighboring gene carboxypeptidase B1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • ACE Inhibitor Pathway, organism-specific biosystem (from WikiPathways)
    ACE Inhibitor Pathway, organism-specific biosystemThe core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by an...
  • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
    Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
    Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Allograft Rejection, organism-specific biosystem (from WikiPathways)
    Allograft Rejection, organism-specific biosystemThis pathway illustrates molecular interactions involved in the fundamental adaptive immune response for allograft destruction. This pathway was adapted in large part from the KEGG pathway http://www...
  • Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
    Angiopoietin receptor Tie2-mediated signaling
  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • Arf6 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 signaling events, organism-specific biosystem
    Arf6 signaling events
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemRecruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Hypothesized Pathways in Pathogenesis of Cardiovascular Disease, organism-specific biosystem (from WikiPathways)
    Hypothesized Pathways in Pathogenesis of Cardiovascular Disease, organism-specific biosystemThe pathways hypothesized to be involved in cardiovascular diseases begin with LTBPs and Fibrillins activating a TGFBR complex. The complex can begin the canonical TGFB pathway involving SMAD protei...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
angiotensin type I receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin type I receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
angiotensin type II receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
bradykinin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
low-density lipoprotein particle remodeling NAS
Non-traceable Author Statement
more info
PubMed 
phospholipase C-activating G-protein coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
phospholipase C-activating angiotensin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NAD(P)H oxidase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cellular protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cholesterol esterification IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
positive regulation of phospholipase A2 activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of reactive oxygen species metabolic process TAS
Traceable Author Statement
more info
PubMed 
regulation of blood vessel diameter IC
Inferred by Curator
more info
PubMed 
regulation of blood vessel diameter by renin-angiotensin IC
Inferred by Curator
more info
PubMed 
regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
regulation of renal sodium excretion NAS
Non-traceable Author Statement
more info
PubMed 
regulation of systemic arterial blood pressure by renin-angiotensin IC
Inferred by Curator
more info
PubMed 
regulation of vasoconstriction IC
Inferred by Curator
more info
PubMed 
regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of vasoconstriction NAS
Non-traceable Author Statement
more info
PubMed 
renin-angiotensin regulation of aldosterone production NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
intracellular IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
type-1 angiotensin II receptor
Names
type-1B angiotensin II receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008468.1 RefSeqGene

    Range
    5001..50133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000685.4NP_000676.1  type-1 angiotensin II receptor isoform 1

    See identical proteins and their annotated locations for NP_000676.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as pC2, hAT1R-B (PubMed ID:16504375) or hAT1R-C (PubMed ID:11158334), encodes the predominant isoform (1). Variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    AC024897, AI240900
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556
    UniProtKB/TrEMBL
    Q53YY0
    Related
    ENSP00000273430.3, OTTHUMP00000215600, ENST00000349243.7, OTTHUMT00000355806
    Conserved Domains (2) summary
    pfam00001
    Location:45302
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37262
    7tm_4; Olfactory receptor
  2. NM_004835.4NP_004826.5  type-1 angiotensin II receptor isoform 2

    See identical proteins and their annotated locations for NP_004826.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as hAT1R-B (PubMed ID:11158334) or hAT1R-C (PubMed ID:16504375), has an alternate exon in the 5' region, which contains an in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform 2.
    Source sequence(s)
    AC024897, AI016286, AV651073, BC022447, DA649921
    Consensus CDS
    CCDS82854.1
    UniProtKB/Swiss-Prot
    P30556
    UniProtKB/TrEMBL
    D3DNG8
    Related
    ENSP00000398832.3, ENST00000418473.6
    Conserved Domains (2) summary
    pfam00001
    Location:80337
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:72297
    7tm_4; Olfactory receptor
  3. NM_009585.3NP_033611.1  type-1 angiotensin II receptor isoform 1

    See identical proteins and their annotated locations for NP_033611.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as pC1 or hAT1R-A, lacks an exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC024897, AI240900
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556
    UniProtKB/TrEMBL
    Q53YY0
    Related
    ENSP00000419422.1, OTTHUMP00000215601, ENST00000497524.5, OTTHUMT00000355807
    Conserved Domains (2) summary
    pfam00001
    Location:45302
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37262
    7tm_4; Olfactory receptor
  4. NM_031850.3NP_114038.4  type-1 angiotensin II receptor isoform 2

    See identical proteins and their annotated locations for NP_114038.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as pC3 or hAT1R-D, has an additional exon in the 5' region, which contains an in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform 2.
    Source sequence(s)
    AC024897, AI016286, AV651073, BC068494, DA649921
    Consensus CDS
    CCDS82854.1
    UniProtKB/TrEMBL
    D3DNG8, Q6NUP5
    Conserved Domains (2) summary
    pfam00001
    Location:80337
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:72297
    7tm_4; Olfactory receptor
  5. NM_032049.3NP_114438.2  type-1 angiotensin II receptor isoform 3

    See identical proteins and their annotated locations for NP_114438.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as pC4, has two additional exons in the 5' region, but its 5' UTR end has not been determined, compared to variant 1. The resulting isoform (3) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC024897, AI016286
    Consensus CDS
    CCDS82855.1
    UniProtKB/TrEMBL
    A0A0A0MSE3
    Related
    ENSP00000385641.2, ENST00000402260.1
    Conserved Domains (2) summary
    pfam00001
    Location:74331
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:66291
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

    Range
    148697871..148743003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    148378782..148423918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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