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AGTR1 angiotensin II receptor type 1 [ Homo sapiens (human) ]

Gene ID: 185, updated on 29-Mar-2023

Summary

Official Symbol
AGTR1provided by HGNC
Official Full Name
angiotensin II receptor type 1provided by HGNC
Primary source
HGNC:HGNC:336
See related
Ensembl:ENSG00000144891 MIM:106165; AllianceGenome:HGNC:336
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AT1; AG2S; AT1B; AT1R; ATR1; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B
Summary
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Expression
Biased expression in placenta (RPKM 58.2), fat (RPKM 27.9) and 9 other tissues See more
Orthologs
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Genomic context

See AGTR1 in Genome Data Viewer
Location:
3q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (148697903..148743003)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (151448936..151494033)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (148415690..148460790)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:148360892-148362091 Neighboring gene RPL38 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:148472851-148473352 Neighboring gene high mobility group box 1 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables angiotensin type I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables angiotensin type I receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables angiotensin type I receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables angiotensin type II receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables bradykinin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in angiotensin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in blood vessel diameter maintenance IC
Inferred by Curator
more info
PubMed 
involved_in calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in low-density lipoprotein particle remodeling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin IC
Inferred by Curator
more info
PubMed 
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in phospholipase C-activating angiotensin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of CoA-transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NAD(P)H oxidase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phospholipase A2 activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of reactive oxygen species metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
involved_in regulation of renal sodium excretion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of systemic arterial blood pressure by renin-angiotensin IC
Inferred by Curator
more info
PubMed 
involved_in regulation of vasoconstriction IC
Inferred by Curator
more info
PubMed 
involved_in regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of vasoconstriction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in renin-angiotensin regulation of aldosterone production NAS
Non-traceable Author Statement
more info
PubMed 
involved_in viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
type-1 angiotensin II receptor
Names
AT1 receptor
type-1B angiotensin II receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008468.2 RefSeqGene

    Range
    5002..50102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000685.5NP_000676.1  type-1 angiotensin II receptor

    See identical proteins and their annotated locations for NP_000676.1

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556, Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9, Q53YY0
    Related
    ENSP00000273430.3, ENST00000349243.8
    Conserved Domains (1) summary
    cd15192
    Location:29313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001382736.1NP_001369665.1  type-1 angiotensin II receptor

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9
    Related
    ENSP00000385612.2, ENST00000404754.2
    Conserved Domains (1) summary
    cd15192
    Location:29313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001382737.1NP_001369666.1  type-1 angiotensin II receptor

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9
    Conserved Domains (1) summary
    cd15192
    Location:29313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_004835.5NP_004826.6  type-1 angiotensin II receptor

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9
    Related
    ENSP00000398832.4, ENST00000418473.7
    Conserved Domains (1) summary
    cd15192
    Location:29313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_009585.4NP_033611.1  type-1 angiotensin II receptor

    See identical proteins and their annotated locations for NP_033611.1

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556, Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9, Q53YY0
    Related
    ENSP00000419422.1, ENST00000497524.5
    Conserved Domains (1) summary
    cd15192
    Location:29313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. NM_031850.4NP_114038.5  type-1 angiotensin II receptor

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9
    Conserved Domains (1) summary
    cd15192
    Location:29313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  7. NM_032049.4NP_114438.3  type-1 angiotensin II receptor

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9
    Related
    ENSP00000385641.3, ENST00000402260.2
    Conserved Domains (1) summary
    cd15192
    Location:29313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    148697903..148743003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    151448936..151494033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)